Postgraduate Program in Tocogynecology, Medicine School - São Paulo State University (UNESP), São Paulo, SP, Brazil.
Department of Mastology and Breast Reconstruction, Barretos Cancer Hospital, Barretos, SP, Brazil.
Breast Dis. 2022;41(1):407-411. doi: 10.3233/BD-220027.
Metastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site.
We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma.
DISCUSSION/CONCLUSION: In the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis.
转移性乳腺癌是一种罕见的疾病，其中对侧乳房转移是最常见的原发性部位。
我们报告了一例接受人乳头瘤病毒（HPV）阳性宫颈鳞状细胞癌（SCC）治疗的患者，在随访期间，她主诉左乳房有一个结节。病理结果显示为鳞状细胞癌，无法与乳腺化生癌区分。进行了病变切除术，证实为具有鳞状细胞分化的癌，GCDFP-15、乳球蛋白、p63 和 SOX10 阴性，但 p16 和高危 HPV 阳性，证实为宫颈癌的单一转移病变。
讨论/结论：在乳房中存在 SCC 时，鉴别诊断可能需要考虑原发性病变、具有鳞状细胞分化的化生癌或转移性疾病。使用 p63、SOX10 和 p16 等标志物可能有助于明确诊断。
