Sun Ce, Zhang Wei Sen, Jiang Chao Qiang, Jin Ya Li, Deng Xue Qing, Thomas G Neil, Woo Jean, Cheng Kar Keung, Lam Tai Hing, Xu Lin
School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Guangzhou, Guangdong Province, China.
Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
Eur J Nutr. 2023 Apr;62(3):1239-1251. doi: 10.1007/s00394-022-03067-8. Epub 2022 Dec 11.
We examined the association between whole grain and refined grain intake with all-cause, cancer and cardiovascular disease (CVD) mortality using the data from the Guangzhou Biobank Cohort Study.
19,597 participants aged 50+ years were recruited from 2003 to 2006 and followed-up until April 2021. Multivariable Cox regression was used to calculate hazard radios (HRs) and 95% confidence intervals (CIs). Substitution analysis was used to replace a serving (50 g/day) of whole grain with a serving of refined grain.
During 286,821 person-years of follow-up, 4385 deaths occurred, including 1450 from cancer, 1678 from CVD and 1257 from other causes. Compared with never whole grain intake, the highest intake category of whole grain (> 300 g/week) was associated with lower risk of all-cause (HR 0.90, 95% CI 0.82-0.98) and CVD mortality (HR 0.85, 0.74-0.98). Compared with the low-intake category of refined grain (< 500 g/day), the highest intake category (> 900 g/week) was associated with a lower risk of cancer mortality (HR 0.76, 0.62-0.95), but a higher risk of CVD mortality (HR 1.25, 1.03-1.51). No significant associations were found between whole grain intake and cancer mortality nor refined grain and all-cause mortality. The HRs of all-cause, cancer and CVD mortality substituting a serving of whole grain for refined grain were 0.96 (0.94-0.99), 1.01 (0.99-1.02) and 0.95 (0.90-0.99), respectively.
We have first shown that in older Chinese, whole grain intake was associated with lower risk of all-cause and CVD mortality. Our results suggest that intake of whole grain of at least 300 g/week and refined grain of ≤ 900 g/day might be suitable for older Asian. Substituting 50 g/day of whole grain for refined grain was associated with a 4-5% lower risk of all-cause and CVD mortality.
我们利用广州生物银行队列研究的数据，研究了全谷物和精制谷物摄入量与全因、癌症和心血管疾病（CVD）死亡率之间的关联。
2003年至2006年招募了19597名年龄在50岁及以上的参与者，并随访至2021年4月。采用多变量Cox回归计算风险比（HRs）和95%置信区间（CIs）。采用替代分析，用一份精制谷物替代一份全谷物（50克/天）。
在286821人年的随访期间，发生了4385例死亡，其中1450例死于癌症，1678例死于心血管疾病，1257例死于其他原因。与从不摄入全谷物相比，全谷物摄入量最高类别（>300克/周）与全因死亡风险较低（HR 0.90，95%CI 0.82-0.98）和心血管疾病死亡率较低（HR 0.85，0.74-0.98）相关。与精制谷物低摄入量类别（<500克/天）相比，最高摄入量类别（>900克/周）与癌症死亡率较低风险（HR 0.76，0.62-0.95）相关，但与心血管疾病死亡率较高风险（HR 1.25，1.03-1.51）相关。未发现全谷物摄入量与癌症死亡率之间以及精制谷物与全因死亡率之间存在显著关联。用一份精制谷物替代一份全谷物时，全因、癌症和心血管疾病死亡率的HR分别为0.96（0.94-0.99）、1.01（0.99-1.02）和0.95（0.90-0.99）。
我们首次表明，在老年中国人中，全谷物摄入量与全因和心血管疾病死亡率较低风险相关。我们的结果表明，每周至少摄入300克全谷物和每天摄入≤900克精制谷物可能适合老年亚洲人。用每天50克全谷物替代精制谷物与全因和心血管疾病死亡率降低4-5%相关。
