Center Armand-Frappier Santé Biotechnologie of the INRS, University of Quebec, Laval, Quebec, Canada.
CNRS UMR 7369 MEDyC, University of Reims Champagne-Ardenne, Reims, France.
Cell Adh Migr. 2023 Dec;17(1):1-13. doi: 10.1080/19336918.2022.2154732.
Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of leads to an inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination . These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in and models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of and reinforce its interest as complementary medicine in oncology.
皮肤黑色素瘤是一种预后非常差的癌症，主要是因为转移和扩散，因此细胞迁移受到了调节。目前的治疗方法可以受益于补充药物作为肿瘤学的支持性护理。在我们的研究中，我们表明，经过动态超稀释处理的 leads 会抑制 B16F10 黑色素瘤细胞在纤维连接蛋白上的迁移，同时减少转移性扩散。这些效果似乎是由于细胞膜组织的破坏，导致细胞和细胞膜硬度的变化，伴随着肌动蛋白细胞骨架的紊乱和质膜脂质组成的改变。总之，这些结果表明，在皮肤黑色素瘤的和 模型中，超动态稀释的 具有抗癌和抗转移活性，并增强了其作为肿瘤学补充药物的应用价值。
