Di Bona Danilo, Miniello Andrea, Nettis Eustachio
Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico di Bari, Bari, Italy.
Unit of Allergology, Azienda Ospedaliero Universitaria Consorziale Policlinico, Bari Piazza Giulio Cesare, 11., 70124, Bari, Italy.
Clin Mol Allergy. 2022 Dec 12;20(1):13. doi: 10.1186/s12948-022-00179-8.
Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is an adverse drug reaction which manifests as a symmetrical erythematous rash involving the skin folds after systemic drug exposure. A vast array of possible side effects associated with administration of different anti-SARS-CoV-2 vaccines have been reported in literature since the beginning of the COVID-19 pandemic, but only few times SDRIFE-like eruptions have been described in this context. We discuss here a case of SDRIFE-like eruption following the second dose of Oxford-Astrazeneca Vaxzevria vaccine.
系统性药物相关的擦烂性和屈侧疹（SDRIFE）是一种药物不良反应，表现为在全身性药物暴露后，皮肤褶皱处出现对称性红斑疹。自新冠疫情开始以来，文献中报道了与不同抗SARS-CoV-2疫苗接种相关的大量可能的副作用，但在此背景下，仅有少数几次描述了类似SDRIFE的皮疹。我们在此讨论一例在接种第二剂牛津-阿斯利康公司的Vaxzevria疫苗后出现类似SDRIFE皮疹的病例。
