2013年至2022年丙型肝炎研究的科学进展与前景
The scientific progress and prospects of hepatitis C research from 2013 to 2022.
作者信息
Tang Xiaowei, Gan Peiling, Huang Shu, Pan Xiao, Wang Ruiyu, Wang Ping, Xia Huifang, Zeng Xinyi, Ren Wensen, Shi Lei, Zhou Xian, Linghu Enqiang
机构信息
Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital Beijing, China.
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
出版信息
Am J Transl Res. 2022 Nov 15;14(11):7806-7819. eCollection 2022.
BACKGROUND AND OBJECTIVE
Hepatitis C (HC) is a global health issue, with an estimated 350,000 people dying annually from this liver-related disease. This study determined the development trends and research hotspots regarding HC by investigating the related articles within the past ten years.
METHODS
Publications on HC were retrieved from the Web of Science Core Collection (WoSCC) on June 6, 2022. Bibliometric visualization was conducted through VOSviewer and CiteSpace. Original articles and reviews served as the foundation for this analytical research.
RESULTS
Of the total 17,773 records of HC research published from 2013 to 2022, the top 1,000 articles were retrieved and distributed among 78 countries and 270 journals. The US, where 7 of the top 10 institutions were located, mainly contributed to the study (51.9%). Johns Hopkins University distributed the most related articles (45 articles). Hepatology (IF 2021 = 17.298) ranked first, with 109 articles in the top 10 journals. Dore GJ was the most productive author (40 articles). The keywords of sustained virologic response, therapy, sofosbuvir, cirrhosis, ledipasvir, and hepatocellular carcinoma offered hints regarding research hotspots. The burst keywords regarding the virus, like HCV, HIV, and care and intervention showed as research frontiers.
CONCLUSIONS
Treatment has been a trending topic in HC research, and future research may focus more on HCV and HIV co-infection, treatment, and elimination of HC.
背景与目的
丙型肝炎（HC）是一个全球性的健康问题，据估计每年有35万人死于这种肝脏相关疾病。本研究通过调查过去十年内的相关文章，确定了HC的发展趋势和研究热点。
方法
于2022年6月6日从科学网核心合集（WoSCC）中检索关于HC的出版物。通过VOSviewer和CiteSpace进行文献计量可视化分析。原始文章和综述作为本分析研究的基础。
结果
在2013年至2022年发表的17773条HC研究记录中，检索到了前1000篇文章，这些文章分布在78个国家和270种期刊中。美国贡献了主要研究成果（51.9%），前10大机构中有7个位于美国。约翰·霍普金斯大学发表的相关文章最多（45篇）。《肝脏病学》（2021年影响因子=17.298）排名第一，在前10种期刊中有109篇文章。多雷·G·J是发文量最高的作者（40篇文章）。持续病毒学应答、治疗、索磷布韦、肝硬化、来迪派韦和肝细胞癌等关键词提示了研究热点。关于病毒的突发关键词，如HCV、HIV以及护理与干预则显示为研究前沿。
结论
治疗一直是HC研究中的一个热门话题，未来的研究可能会更多地聚焦于HCV与HIV合并感染、HC的治疗和消除。
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