Oh S J, Clements R S, Lee Y W, Diethelm A G
Ann Neurol. 1978 Oct;4(4):369-73. doi: 10.1002/ana.410040413.
In 12 patients with chronic renal failure who received kidney transplants from either cadavers (6) or related living donors (6), rapid improvement in median sensory and motor nerve conduction velocities (NCVs) was observed within a few days after transplantation. The postoperative improvement in median sensory NCV was found to bear a statistically significant negative correlation with creatinine and myo-inositol concentrations. We suggest that metabolic phenomena are responsible for the rapid improvement in median sensory NCV following renal transplantation. The close relationship between myo-inositol and the median sensory NCV following transplantation suggests that elevated plasma myo-inositol concentrations may be related to nerve conduction abnormalities in uremic polyneuropathy.
在12例接受尸体（6例）或亲属活体供肾移植的慢性肾衰竭患者中，移植后数天内观察到正中神经感觉和运动神经传导速度（NCV）中位数迅速改善。发现术后正中神经感觉NCV的改善与肌酐和肌醇浓度呈统计学显著负相关。我们认为，代谢现象是肾移植后正中神经感觉NCV迅速改善的原因。移植后肌醇与正中神经感觉NCV之间的密切关系表明，血浆肌醇浓度升高可能与尿毒症性多发性神经病的神经传导异常有关。
