Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Blvd 99, 8200 Aarhus N, Denmark.
Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Blvd 99, 8200 Aarhus N, Denmark.
Eur J Prev Cardiol. 2023 Aug 21;30(11):1046-1053. doi: 10.1093/eurjpc/zwac293.
Alcohol intake is a well-established risk factor for atrial fibrillation (AF). However, evidence on the effects of changes in alcohol intake to primary AF prevention is sparse. The aim of this study was to examine the association between 5-year changes in alcohol intake and the risk of incident AF.
This study was based on the Danish cohort study Diet, Cancer and Health. Lifestyle factors were assessed using questionnaires at a recruitment research examination and a second examination 5 years later. Diagnoses of AF and comorbidities were retrieved from the Danish National Patient Registry. 43 758 participants without prior AF were included. The median age was 61 (25th-75th percentile 58-66) years and 54% were female. Over a median follow-up time of 15.7 years, 5312 participants had incident AF (incidence rate 8.6/1000 person-years). Compared with stable intake, increases in alcohol intake to ≥21 drinks/week from ≤6.9 drinks/week (HR: 1.38, 95% CI: 1.09-1.72) or 14-20.9 drinks/week (HR: 1.27, 95% CI: 1.01-1.59) at baseline were associated with a higher risk of AF. In contrast, we did not observe a statistically significant association between reductions in alcohol intake and the risk of AF.
A 5-year increase in alcohol intake was associated with a greater risk of AF compared with a stable low/moderate intake.
饮酒是房颤（AF）的一个明确的危险因素。然而，关于饮酒量变化对原发性 AF 预防效果的证据很少。本研究旨在探讨 5 年内饮酒量变化与新发 AF 风险之间的关系。
本研究基于丹麦队列研究 Diet, Cancer and Health。生活方式因素在招募研究检查和 5 年后的第二次检查中通过问卷进行评估。AF 和合并症的诊断从丹麦国家患者登记处检索。共纳入 43758 名无既往 AF 的参与者。中位年龄为 61 岁（25-75 百分位数 58-66），54%为女性。中位随访时间为 15.7 年，5312 名参与者发生了 AF（发病率为 8.6/1000 人年）。与稳定饮酒相比，从≤6.9 份/周增加到≥21 份/周（HR：1.38，95%CI：1.09-1.72）或从 14-20.9 份/周增加（HR：1.27，95%CI：1.01-1.59）与 AF 风险增加相关。相反，我们没有观察到饮酒量减少与 AF 风险之间存在统计学显著关联。
与稳定的低/中度饮酒相比，5 年内饮酒量增加与 AF 风险增加相关。
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