饮酒与新发心房颤动风险：基于人群的队列研究。

Alcohol consumption and risk of incident atrial fibrillation: A population-based cohort study.

机构信息

Department of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, 931 86 Skellefteå, Sweden.

出版信息

Eur J Intern Med. 2020 Jun;76:50-57. doi: 10.1016/j.ejim.2020.02.022. Epub 2020 Mar 6.

DOI:10.1016/j.ejim.2020.02.022

PMID:32147331

Abstract

AIMS

Atrial fibrillation (AF) is a common tachyarrhythmia. High alcohol consumption is associated with increased AF risk. It remains unclear whether lower levels of alcohol consumption are also associated with AF risk, and whether the association differs between men and women. In this study, we investigated the association between low to moderate levels of alcohol consumption and AF risk in men and women.

METHODS

We performed a population-based cohort study of 109,230 health examination participants in northern Sweden. Data regarding alcohol intake were obtained using a questionnaire administered at the health examination. Incident AF cases were identified from the Swedish National Patient Registry.

RESULTS

AF was diagnosed in 5,230 individuals during a total follow-up of 1,484,547 person-years. Among men, AF risk increased over quartiles of weekly alcohol consumption (P for trend 0.001). Men with alcohol consumption in the highest quartile (≥4.83 standard drinks [each drink containing 12 gs of ethanol] per week; SDW) had a HR of 1.21 (95% CI 1.09-1.34) for AF compared to men in the lowest quartile (<0.90 SDW). In men, problem drinking was also associated with an increased AF risk (HR: 1.24; 95% CI: 1.10-1.39). Among women, AF risk was not significantly associated with alcohol consumption (P for trend 0.09 for decreasing risk of AF over quartiles of weekly alcohol consumption) or problem drinking (HR: 1.00; 95% CI 0.70-1.42).

CONCLUSION

Self-reported alcohol consumption and problem drinking were associated with an increased risk of AF among men, but not in women.

摘要

目的

心房颤动（AF）是一种常见的快速性心律失常。大量饮酒与 AF 风险增加相关。目前尚不清楚较低水平的饮酒是否也与 AF 风险相关，以及这种关联在男性和女性之间是否存在差异。在这项研究中，我们调查了低至中度饮酒水平与男性和女性 AF 风险之间的关联。

方法

我们对瑞典北部的 109230 名健康检查参与者进行了一项基于人群的队列研究。使用健康检查时进行的问卷调查获得有关饮酒量的数据。通过瑞典国家患者登记处确定 AF 病例。

结果

在 1484547 人年的总随访期间，共诊断出 5230 例 AF。在男性中，AF 风险随着每周饮酒量的四分位数增加而增加（趋势 P 值<0.001）。与每周饮酒量最低四分位数（<0.90 SDW）的男性相比，每周饮酒量最高四分位数（≥4.83 标准杯[每杯含 12 克乙醇]）的男性患 AF 的 HR 为 1.21（95%CI 1.09-1.34）。在男性中，酗酒也与 AF 风险增加相关（HR：1.24；95%CI：1.10-1.39）。在女性中，饮酒量与 AF 风险无显著相关性（趋势 P 值为 0.09，提示随着每周饮酒量的四分位数减少，AF 风险降低）或酗酒（HR：1.00；95%CI 0.70-1.42）。