Xin Chengqi, Guan Xin, Wang Liang, Liu Jing
Stem Cell Clinical Research Center, The First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, 116011, Dalian City, Liaoning Province, P.R. China.
Dalian Innovation Institute of Stem Cell and Precision Medicine, No. 57, Xinda Street, Dalian High-Tech Park, 116023, Dalian City, Liaoning Province, P.R. China.
Neurochem Res. 2023 May;48(5):1269-1279. doi: 10.1007/s11064-022-03839-y. Epub 2022 Dec 13.
Cerebral palsy (CP) describes a heterogeneous group of non-progressive neurodevelopmental disorders affecting movement and posture. The etiology and diagnostic biomarkers of CP are a hot topic in clinical research. Recent advances in omics techniques, including genomics, epigenomics, transcriptomics, metabolomics and proteomics, have offered new insights to further understand the pathophysiology of CP and have allowed for identification of diagnostic biomarkers of CP. In present study, we reviewed the latest multi-omics investigations of CP and provided an in-depth summary of current research progress in CP. This review will offer the basis and recommendations for future fundamental research on the pathogenesis of CP, identification of diagnostic biomarkers, and prevention strategies for CP.
脑瘫（CP）是一组影响运动和姿势的异质性非进行性神经发育障碍。脑瘫的病因和诊断生物标志物是临床研究中的热点话题。包括基因组学、表观基因组学、转录组学、代谢组学和蛋白质组学在内的组学技术的最新进展，为进一步理解脑瘫的病理生理学提供了新的见解，并有助于识别脑瘫的诊断生物标志物。在本研究中，我们回顾了脑瘫的最新多组学研究，并对脑瘫的当前研究进展进行了深入总结。本综述将为未来关于脑瘫发病机制的基础研究、诊断生物标志物的识别以及脑瘫的预防策略提供依据和建议。
