Smith S A, Stallard T J, Salih M M, Littler W A
Department of Cardiovascular Medicine, University of Birmingham, East Birmingham Hospital.
Cardiovasc Res. 1987 Jun;21(6):422-7. doi: 10.1093/cvr/21.6.422.
A new time related method of analysing the sinoaortic baroreceptor heart rate reflex, which determines reflex latency as well as sensitivity, was used to compare the results obtained with a phenylephrine ramp method (P) with those obtained using the whole of phase IV of Valsalva (V1) and using the phase IV systolic blood pressure overshoot alone (V2). Twenty five subjects with large ranges of age and resting blood pressures were studied. Each performed two standardised Valsalva manoeuvres and received three bolus injections of phenylephrine sufficient to cause transient pressor responses of 20-30 mmHg. Mean sensitivity values with P (6.2(3.5) ms.mmHg-1) were greater than those with V1 (4.6(2.3) ms.mmHg-1, p less than 0.001) and less than V2 (7.8(4.0) ms.mmHg-1, p less than 0.001). However, linear regression analysis showed a correlation of P with V1 (r = 0.76, p less than 0.0001) and with V2 (r = 0.80, p less than 0.0001). Reflex latency with P (1084(427) ms) was less than V1 (2416(423) ms, p less than 0.0001) and V2 (1504(441) ms, p less than 0.0005). Reflex sensitivity results obtained using phase IV of Valsalva's manoeuvre are proportionately related to phenylephrine results, but large errors were introduced into the absolute values obtained when relatively small changes were made to the method of analysis.
一种新的与时间相关的分析窦主动脉压力感受器心率反射的方法，该方法可测定反射潜伏期和敏感性，用于比较用去氧肾上腺素斜坡法（P）、瓦尔萨尔瓦动作整个IV期（V1）以及仅使用IV期收缩压过冲（V2）所获得的结果。研究了25名年龄和静息血压范围较大的受试者。每位受试者进行两次标准化的瓦尔萨尔瓦动作，并接受三次去氧肾上腺素推注，足以引起20 - 30 mmHg的短暂升压反应。P法的平均敏感性值（6.2(3.5) ms·mmHg⁻¹）大于V1法（4.6(2.3) ms·mmHg⁻¹，p < 0.001）且小于V2法（7.8(4.0) ms·mmHg⁻¹，p < 0.001）。然而，线性回归分析显示P与V1（r = 0.76，p < 0.0001）以及与V2（r = 0.80，p < 0.0001）具有相关性。P法的反射潜伏期（1084(427) ms）小于V1法（2416(423) ms，p < 0.0001）和V2法（1504(441) ms，p < 0.0005）。使用瓦尔萨尔瓦动作IV期获得的反射敏感性结果与去氧肾上腺素结果成比例相关，但当分析方法有相对较小改变时，所获得的绝对值会引入较大误差。
