National Institute for Public Health and the Environment-RIVM, Bilthoven, The Netherlands.
J Expo Sci Environ Epidemiol. 2023 Nov;33(6):971-979. doi: 10.1038/s41370-022-00509-7. Epub 2022 Dec 15.
To ascertain the safe use of chemicals that are used in multiple consumer products, the aggregate human exposure, arising from combined use of multiple consumer products needs to be assessed.
In this work the Probabilistic Aggregate Consumer Exposure Model (PACEM) is presented and discussed. PACEM is implemented in the publicly available web tool, PACEMweb, for aggregate consumer exposure assessment.
PACEM uses a person-oriented simulation method that is based on realistic product usage information obtained in surveys from several European countries. PACEM evaluates aggregate exposure in a population considering individual use and co-use patterns as well as variation in product composition. Product usage data is included on personal care products (PCPs) and household cleaning products (HCPs).
PACEM has been implemented in a web tool that supports broad use in research as well as regulatory risk assessment. PACEM has been evaluated in a number of applications, testing and illustrating the advantage of the person-oriented modeling method. Also, PACEM assessments have been evaluated by comparing its results with biomonitoring information.
PACEM enables the assessment of realistic aggregate exposure to chemicals in consumer products. It provides detailed insight into the distribution of exposure in a population as well as products that contribute the most to exposure. This allows for better informed decision making in the risk management of chemicals.
Realistic assessment of the total, aggregate exposure of consumers to chemicals in consumer products is necessary to guarantee the safe use of chemicals in these products. PACEMweb provides, for the first time, a publicly available tool to assist in realistic aggregate exposure assessment of consumers to chemicals in consumer products.
为了确定在多种消费产品中使用的化学品的安全使用，需要评估来自多种消费产品联合使用的综合人体暴露量。
本文介绍并讨论了概率综合消费者暴露模型（PACEM）。PACEM 已在公共可用的网络工具 PACEMweb 中实现，用于综合消费者暴露评估。
PACEM 使用基于从几个欧洲国家的调查中获得的现实产品使用信息的面向个人的模拟方法。PACEM 考虑个人使用和共同使用模式以及产品成分的变化，评估人群中的综合暴露。产品使用数据包括个人护理产品 (PCPs) 和家用清洁产品 (HCPs)。
PACEM 已在网络工具中实现，支持广泛用于研究和监管风险评估。PACEM 已在多个应用程序中进行了评估，测试并说明了面向个人的建模方法的优势。此外，还通过将其结果与生物监测信息进行比较来评估 PACEM 评估。
PACEM 能够评估消费产品中化学物质的综合暴露情况。它提供了对人群中暴露分布以及对暴露贡献最大的产品的详细了解。这使得在化学品风险管理中能够做出更明智的决策。
为了保证消费产品中化学品的安全使用，有必要对消费者对化学品的综合暴露量进行真实评估。PACEMweb 首次提供了一种公共可用的工具，以协助对消费产品中消费者的化学物质的综合暴露进行真实评估。
