Bruneval P, Mesnildrey P, Camilleri J P
Laboratoire d'Anatomie Pathologique, Hôpital Broussais, Paris, France.
Eur Heart J. 1987 Jul;8(7):785-92. doi: 10.1093/eurheartj/8.7.785.
To characterize myocardial lesions induced by Nd-YAG laser in vivo, laser pulses were delivered on the epicardial surface of beating dog hearts. Acute lesions were studied at the optical and ultrastructural levels. The size of the lesions depended on the power of the laser beam. Tissue vaporization could be avoided if total delivered energy did not exceed 350 J. Laser energy induced different types of myocardial necrosis distributed in concentric layers of coagulation necrosis, and contraction band necrosis. Thus, laser energy can produce controlled irreversible lesions without crater formation. These effects may be of use in the treatment of arrhythmias.
为了在体内表征钕钇铝石榴石激光诱导的心肌损伤，将激光脉冲发射到跳动的犬心脏的心外膜表面。在光学和超微结构水平研究急性损伤。损伤的大小取决于激光束的功率。如果总输送能量不超过350焦耳，可避免组织汽化。激光能量诱导了不同类型的心肌坏死，分布在凝固性坏死和收缩带坏死的同心层中。因此，激光能量可以产生可控的不可逆损伤而不形成火山口。这些效应可能在心律失常的治疗中有用。
