Inhibitory effects of postbiotic consisting sonication-killed on experimental triple negative breast neoplasm in mice: a preliminary study.

BACKGROUND AND OBJECTIVES

Breast cancer is the second leading cause of death and one of the most common malignancies among women in the world. The aim of this study was to investigate the preventive effects of postbiotic consisting of sonicated cells on triple negative breast cancer.

MATERIALS AND METHODS

Thirty-six female BALB/c mice aged 5-7 weeks were randomly divided into 3 groups (n=12): Ctrl-, healthy mice; Ctrl+, mice with breast cancer with no treatment; and Postbiotic, mice with orally gavage postbiotic before and after 4T1 cell line transplantation. Cancer progress and the effects of postbiotic were assayed by histological, immunohistochemical and gene expression quantification.

RESULTS

The histological results showed that administration postbiotic consisting of significantly decreased carcinogenesis in terms of tumor incidence, multiplicity and volume. The tumor progress was suppressed by oral intake of as showed by p53 and Ki-67 expression. Furthermore, Oral intake of postbiotic resulted in extended survival of mice and inhibited sever weigh loss.

CONCLUSION

Pretreatment with sonication killed as a postbiotic, inhibited breast cancer progress and malignancy.