Homayouni Rad Aziz, Aghebati Maleki Leili, Samadi Kafil Hossein, Fathi Zavoshti Hamideh, Abbasi Amin
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2021 Jan;11(1):1-5. doi: 10.34172/apb.2021.007. Epub 2020 Nov 7.
As many investigations have reported, there is a complicated relation between fermented foods, lactic acid bacteria (LAB), and human health. It seems that bioactive components such as prebiotics, probiotics, and postbiotics are key mediators of the complex and direct association between these factors. LAB activity in the matrix of fermented foods and improving their growth by prebiotic compounds ultimately results in the production of bioactive molecules (postbiotics), which possess specific biological and physiological properties. The term "postbiotics" refers to a complex of biological micro- and macromolecules, if consumed in adequate amounts, provides the host with different health-promoting effects. Different reports have suggested that postbiotics possess the ability to moderate the effectiveness of cancer treatment and reduce the side-effects of conventional therapies in cancer patients due to their anti-proliferative, anti-inflammatory and anti-cancer properties. Consequently, postbiotics, for their unique characteristics, have gained great scientific attention and are considered as a novel approach for adjuvant therapy in patients with cancer.
正如许多调查所报道的，发酵食品、乳酸菌（LAB）与人类健康之间存在复杂的关系。益生元、益生菌和后生元等生物活性成分似乎是这些因素之间复杂而直接关联的关键调节因子。乳酸菌在发酵食品基质中的活性以及益生元化合物对其生长的促进作用最终导致生物活性分子（后生元）的产生，这些分子具有特定的生物学和生理学特性。“后生元”一词指的是生物小分子和大分子的复合物，若适量摄入，可为宿主带来不同的健康促进作用。不同的报道表明，后生元因其抗增殖、抗炎和抗癌特性，具有调节癌症治疗效果并减轻癌症患者传统疗法副作用的能力。因此，后生元因其独特的特性而受到了极大的科学关注，并被视为癌症患者辅助治疗的一种新方法。
