Long Jiaxin, Wang Jinlong, Li Yang, Chen Shuai
Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
Front Nutr. 2022 Dec 1;9:1008514. doi: 10.3389/fnut.2022.1008514. eCollection 2022.
Gut microbiota is increasingly recognized to affect host health and disease, including ischemic stroke (IS). Here, we systematically review the current understanding linking gut microbiota as well as the associated metabolites to the pathogenesis of IS (e.g., oxidative stress, apoptosis, and neuroinflammation). Of relevance, we highlight that the implications of gut microbiota-dependent intervention could be harnessed in orchestrating IS.
肠道微生物群越来越被认为会影响宿主健康和疾病，包括缺血性中风（IS）。在此，我们系统地综述了目前关于肠道微生物群及其相关代谢产物与IS发病机制（如氧化应激、细胞凋亡和神经炎症）之间联系的认识。与此相关的是，我们强调肠道微生物群依赖性干预的意义可用于调控IS。
