雷尼替丁对阿司匹林吸收的影响。
Effect of ranitidine on the absorption of aspirin.
作者信息
Corrocher R, Bambara L M, Caramaschi P, Testi R, Girelli M, Pellegatti M, Lomeo A
机构信息
Institute of Medical Pathology, University of Verona, Italy.
出版信息
Digestion. 1987;37(3):178-83. doi: 10.1159/000199497.
Six healthy male volunteers received 1 week's pretreatment with ranitidine, 150 mg twice daily, and placebo in a double-blind cross-over trial. On the 8th day, each volunteer received 1 g of aspirin in order to study the pharmacokinetics of this nonsteroidal anti-inflammatory drug. The results of this study suggest that ranitidine does not induce clinically significant alterations to the kinetics of a single dose of aspirin in healthy males.
在一项双盲交叉试验中，六名健康男性志愿者接受了为期1周的雷尼替丁预处理，剂量为每日两次，每次150毫克，同时还接受了安慰剂。在第8天，每名志愿者服用了1克阿司匹林，以研究这种非甾体抗炎药的药代动力学。该研究结果表明，雷尼替丁不会在健康男性中引起单剂量阿司匹林动力学的临床显著改变。
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