Rostock University Medical Center, Rostock, Germany.
University of Rostock, Rostock, Germany.
Integr Cancer Ther. 2022 Jan-Dec;21:15347354221143064. doi: 10.1177/15347354221143064.
This study retrospectively examined the association between cancer-related fatigue (CrF) and the number of falls during the last 12 months in patients with myeloproliferative neoplasms (MPNs).
A multicenter, 1-time anonymous survey was conducted using analog and digital questionnaires. Sex-stratified multinomial logistic regression analysis was applied to investigate the association between CrF and number of falls. All analyses were adjusted for age, school education, body mass index, MPN subtype, and quality of life.
The final sample comprised 688 patients (mean age 57.4 ± 13.8, 62.4% women). The fall rate was 16.2% in women and 12.2% in men ( = .153). There were no differences between women and men in terms of CrF between individuals with more than 1 fall, whereas women with 1 fall had a higher CrF compared to those without a fall (RRR = 1.019; 95% CI [1.002-1.039]), respectively.
CrF increases the risk of falls in women with MPN. Physicians should evaluate and manage CrF symptoms and implement fall prevention strategies for those who are at increased risk. Further research is needed to better understand the effects of CrF on gait performance and associated fall risk.
本研究回顾性分析了癌症相关疲乏（CrF）与过去 12 个月内骨髓增殖性肿瘤（MPN）患者跌倒次数之间的关系。
采用模拟和数字问卷进行多中心、一次性匿名调查。应用分层多分类逻辑回归分析调查 CrF 与跌倒次数之间的关系。所有分析均调整了年龄、学校教育程度、体重指数、MPN 亚型和生活质量。
最终样本包括 688 例患者（平均年龄 57.4±13.8 岁，62.4%为女性）。女性的跌倒率为 16.2%，男性为 12.2%（ = .153）。在跌倒次数较多的女性和男性中，CrF 之间没有差异，而跌倒 1 次的女性与未跌倒的女性相比，CrF 更高（RRR = 1.019；95% CI [1.002-1.039]）。
CrF 增加了 MPN 女性跌倒的风险。医生应评估和管理 CrF 症状，并为那些有更高风险的患者实施跌倒预防策略。需要进一步研究以更好地了解 CrF 对步态表现和相关跌倒风险的影响。
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