Felser Sabine, Rogahn Julia, le Coutre Philipp, Al-Ali Haifa Kathrin, Schulze Susann, Muegge Lars-Olof, Gruen Julia, Geissler Jan, Kraze-Kliebhahn Veronika, Junghanss Christian
Department of Internal Medicine, Clinic III - Hematology, Oncology and Palliative Care, Rostock University Medical Center, Rostock, Germany.
Department of Hematology, Oncology, and Cancer Immunology, Charité Campus Virchow-Klinikum, Charité, Universitätsmedizin Berlin, Berlin, Germany.
Front Oncol. 2023 Jan 4;12:1056786. doi: 10.3389/fonc.2022.1056786. eCollection 2022.
Physical activity (PA) is a non-pharmacological approach to alleviate symptom burden and improve health-related quality of life (HrQoL) in cancer patients (pts). Whether pts with myeloproliferative neoplasms (MPN) PA behavior changes due to symptom burden and/or knowledge of the putative beneficial effects of PA has not yet been investigated.
We performed a large questionnaire study in MPN pts. Self-reported PA behavior and potential influencing factors of 634 MPN pts were analyzed. Questionnaires were used to assess demographics, anxiety, severity of symptoms, HrQoL, current level of everyday and sports activities, and the level of information regarding the importance/possibilities of PA. According to their PA, the pts were assigned to the three groups: "inactive", "non-targeted active", and "sporty active" and compared with each other.
Key findings are that in 73% of the pts, the disease had an impact on PA, with 30% of pts reducing their PA. The prevalence of anxieties (e.g., occurrence of thrombosis and bleeding) regarding PA was 45%. Sporty active pts had a lower symptom burden and better HrQoL ( ≤ 0.001) compared to the other groups. Inactive pts were significantly older and had a higher body mass index than sporty active pts. Inactive and non-targeted active pts felt less informed about the importance/possibilities of PA ( = 0.002).
Our results suggest that especially older and non-sporty MPN pts could benefit from motivational as well as disease-specific PA information. This study was registered at the German Registry of Clinical Trials, DRKS00023698.
体育活动（PA）是一种非药物方法，可减轻癌症患者（pts）的症状负担并改善健康相关生活质量（HrQoL）。骨髓增殖性肿瘤（MPN）患者的PA行为是否因症状负担和/或对PA假定有益效果的了解而发生变化尚未得到研究。
我们对MPN患者进行了一项大型问卷调查研究。分析了634名MPN患者自我报告的PA行为及潜在影响因素。问卷用于评估人口统计学特征、焦虑、症状严重程度、HrQoL、日常和体育活动的当前水平，以及关于PA重要性/可能性的信息水平。根据他们的PA情况，将患者分为三组：“不活动”、“无目标活动”和“积极运动”，并相互比较。
主要发现是，73%的患者中，疾病对PA有影响，30%的患者减少了PA。对PA的焦虑（如血栓形成和出血的发生）患病率为45%。与其他组相比，积极运动的患者症状负担更低，HrQoL更好（≤0.001）。不活动的患者明显比积极运动的患者年龄更大，体重指数更高。不活动和无目标活动的患者对PA的重要性/可能性了解较少（=0.002）。
我们的结果表明，尤其是年龄较大且不运动的MPN患者可能会从动机性以及疾病特异性的PA信息中受益。本研究已在德国临床试验注册中心注册，注册号为DRKS00023698。
