醋丁洛尔治疗室上性心律失常

Acebutolol in supraventricular arrhythmias.

作者信息

Aronow W S, Van Camp S, Turbow M, Whittaker K, Lurie M

出版信息

Clin Pharmacol Ther. 1979 Feb;25(2):149-53. doi: 10.1002/cpt1979252149.

DOI:10.1002/cpt1979252149

Abstract

The effect of intravenous acebutolol on supraventricular arrhythmias was evaluated in 20 patients, 5 with chronic obstructive pulmonary disease. A rapid ventricular rate in atrial fibrillation was slowed greater than 15% in all of 10 patients by acebutolol and in none of 5 patients by saline. A rapid ventricular rate in atrial flutter was slowed greater than 15% in all of 6 patients by acebutolol and in none of 3 patients by saline. Frequent premature atrial beats were abolished or reduced by greater than 75% in each of 2 patients by acebutolol and not in a patient by saline. Acebutolol converted multifocal atrial tachycardia to sinus rhythm in a patient. Digitalis-induced nonparoxysmal atrioventricular junctional tachycardia was not affected by saline but was abolished by acebutolol in a patient. Acebutolol was well tolerated in each of 5 patients with chronic obstructive pulmonary disease. Acebutolol is useful in the treatment of supraventricular arrhythmias.

摘要

对20例患者（其中5例患有慢性阻塞性肺疾病）评估了静脉注射醋丁洛尔对室上性心律失常的疗效。在10例患者中，醋丁洛尔使房颤时的快速心室率减慢超过15%，而5例患者中生理盐水未使其减慢。在6例患者中，醋丁洛尔使房扑时的快速心室率减慢超过15%，而3例患者中生理盐水未使其减慢。在2例患者中，醋丁洛尔使频发房性早搏消失或减少超过75%，而生理盐水未使1例患者的早搏减少。醋丁洛尔使1例患者的多源性房性心动过速转为窦性心律。洋地黄引起的非阵发性房室交界性心动过速不受生理盐水影响，但醋丁洛尔使1例患者的该心律失常消失。5例慢性阻塞性肺疾病患者对醋丁洛尔耐受性良好。醋丁洛尔对室上性心律失常的治疗有效。