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前列腺素在高血压发病机制中的作用。

The role of prostaglandins in the pathogenesis of hypertension.

作者信息

Markov C M

出版信息

Clin Sci Mol Med Suppl. 1978 Dec;4:207s-210s. doi: 10.1042/cs055207s.

DOI:10.1042/cs055207s
PMID:365432
Abstract
  1. Biosynthesis of PGE2 from [14C]arachidonic acid has been found to be lower and PGF2alpha higher in the renal medulla of spontaneously hypertensive (SH) rats than in normal Wistar (NW) rats. 2. Biosynthesis of prostacyclin (PGF1alpha) from [14C]arachidonic acid was decreased in lungs, aorta and heart of SH rats. 3. Metabolism of [3H]PGF1alpha was decreased in renal cortex and lungs and PGE2 increased in SH rats in comparison with NW rats. Thus the lungs of SH rats let more PGF and less PGE enter the systemic circulation. 4. Emotional stress decreased the metabolism of [3H]PGF1alpha in lungs of SH and NW rats, the effect being less in SH rats.
摘要
  1. 已发现，与正常Wistar（NW）大鼠相比，自发性高血压（SH）大鼠肾髓质中由[14C]花生四烯酸合成前列腺素E2（PGE2）的量较低，而前列腺素F2α（PGF2α）的量较高。2. SH大鼠肺、主动脉和心脏中由[14C]花生四烯酸合成前列环素（PGI1α）的量减少。3. 与NW大鼠相比，SH大鼠肾皮质和肺中[3H]PGF1α的代谢减少，PGE2增加。因此，SH大鼠的肺使更多的PGF和更少的PGE进入体循环。4. 情绪应激降低了SH和NW大鼠肺中[3H]PGF1α的代谢，SH大鼠的这种作用较小。

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