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MACC1与结肠腺癌的肿瘤进展和免疫细胞浸润相关，并受lncRNA ZFAS1/miR-642a-5p轴调控。

MACC1 Correlates with Tumor Progression and Immune Cell Infiltration of Colon Adenocarcinoma and is Regulated by the lncRNA ZFAS1/miR-642a-5p Axis.

作者信息

Liu Bi-Xia, Yang Jing, Zeng Chunyan, Chen Youxiang

机构信息

Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, China.

出版信息

J Oncol. 2022 Dec 12;2022:8179208. doi: 10.1155/2022/8179208. eCollection 2022.

DOI:10.1155/2022/8179208
PMID:36545127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9763013/
Abstract

Colon adenocarcinoma (COAD) is the most common pathologic type of colon cancer. Metastasis is responsible for the high mortality rate of patients with COAD. The gene, metastasis-associated in colon cancer 1 (1), is a biomarker predictive of both metastatic and metastasis-free survival in patients with colon cancer and other solid tumors. However, the underlying mechanism by which 1 affect COAD progression and metastasis remains unknown. In this study, we analyzed the expression level and prognostic value of 1, as well as their correlation, in patients with various types of cancer included in The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. High 1 expression was found to be significantly associated with poor prognosis in patients with COAD. Analysis of the potential upstream miRNA of 1 showed that miR-642a-5p was downregulated in COAD and was negatively correlated with 1 expression. Analysis of the upstream regulators of miR-642a-5p showed that the long non-coding RNA (lncRNA) ZFAS1was the most likely upstream regulator of miR-642a-5p. In addition, the expression of 1 correlated positively with tumor immune cell infiltration, as well as with the levels of biomarkers of five kinds of immune cells. In summary, these findings suggest that 1 contributes to COAD progression and immune cell infiltration via the ZFAS1/miR-642a-5p/1 axis.

摘要

结肠腺癌（COAD）是结肠癌最常见的病理类型。转移是导致COAD患者高死亡率的原因。结肠癌转移相关基因1（1）是一种生物标志物，可预测结肠癌和其他实体瘤患者的转移及无转移生存期。然而，1影响COAD进展和转移的潜在机制仍不清楚。在本研究中，我们分析了癌症基因组图谱（TCGA）和基因型-组织表达（GTEx）数据库中各类癌症患者中1的表达水平、预后价值及其相关性。研究发现，1高表达与COAD患者的不良预后显著相关。对1潜在上游miRNA的分析表明，miR-642a-5p在COAD中表达下调，且与1的表达呈负相关。对miR-642a-5p上游调节因子的分析表明，长链非编码RNA（lncRNA）ZFAS1最有可能是miR-642a-5p的上游调节因子。此外，1的表达与肿瘤免疫细胞浸润以及五种免疫细胞生物标志物的水平呈正相关。总之，这些发现表明1通过ZFAS1/miR-642a-5p/1轴促进COAD进展和免疫细胞浸润。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/72dab77fbc28/JO2022-8179208.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/be5422e5c6d1/JO2022-8179208.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/72dab77fbc28/JO2022-8179208.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/91afc5672412/JO2022-8179208.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/c49d53a963cd/JO2022-8179208.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/abeec570c4f0/JO2022-8179208.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/c357aebd1604/JO2022-8179208.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/6de225f8c36c/JO2022-8179208.007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09fe/9763013/72dab77fbc28/JO2022-8179208.009.jpg

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