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具有原型机械心肺复苏波形压缩的血液循环数学模型。

Mathematical Model of Blood Circulation with Compression of the Prototype's Mechanical CPR Waveform.

作者信息

Xu Xingyuan, Wang Shaoping, Wang Shangyu, Liu Guiling

机构信息

School of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, China.

Beihang Ningbo Research Institute, Ningbo 315800, China.

出版信息

Bioengineering (Basel). 2022 Dec 14;9(12):802. doi: 10.3390/bioengineering9120802.

DOI:10.3390/bioengineering9120802
PMID:36551008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9774312/
Abstract

The waveform of chest compressions directly affects the blood circulation of patients with cardiac arrest. Currently, few pieces of research have focused on the influence of the cardiopulmonary resuscitation (CPR) device's mechanical waveform on blood circulation. This study investigates the effect of the mechanical waveform from a novel CPR prototype on blood circulation and explores the optimal compression parameters of the mechanical waveform to optimize blood circulation. A novel CPR prototype was designed and built to establish a kinetic model during compressions. The prototype's mechanical waveforms at various operating conditions were obtained for comparison with manual waveforms and the investigation of the optimal compression parameters. The novel CPR prototype can complete chest compressions quickly and stably. The cardiac output (CO), coronary perfusion pressure (CPP), and cerebral flow (CF) obtained by mechanical waveform compressions (1.22367 ± 0.00942 L/min, 30.95083 ± 0.24039 mmHg, 0.31992 ± 0.00343 L/min, respectively) were significantly better than those obtained by manual waveform compressions (1.10783 ± 0.03601 L/min, 21.39210 ± 1.42771 mmHg, 0.29598 ± 0.01344 L/min, respectively). With the compression of the prototype, the blood circulation can be optimized at the compression depth of 50 mm, approximately 0.6 duty cycle, and approximately 110 press/min, which is of guiding significance for the practical use of CPR devices to rescue patients with cardiac arrest.

摘要

胸外按压的波形直接影响心脏骤停患者的血液循环。目前，很少有研究关注心肺复苏（CPR）设备的机械波形对血液循环的影响。本研究调查了一种新型CPR原型机的机械波形对血液循环的影响，并探索了机械波形的最佳按压参数以优化血液循环。设计并制造了一种新型CPR原型机，以建立按压过程中的动力学模型。获取了该原型机在各种操作条件下的机械波形，以便与手动波形进行比较，并研究最佳按压参数。该新型CPR原型机能够快速、稳定地完成胸外按压。通过机械波形按压获得的心输出量（CO）、冠状动脉灌注压（CPP）和脑血流量（CF）（分别为1.22367±0.00942 L/min、30.95083±0.24039 mmHg、0.31992±0.00343 L/min）明显优于手动波形按压获得的结果（分别为1.10783±0.03601 L/min、21.39210±1.42771 mmHg、0.29598±0.01344 L/min）。随着原型机的按压，在按压深度为50 mm、占空比约为0.6、按压频率约为110次/分钟时，血液循环可得到优化，这对CPR设备实际用于抢救心脏骤停患者具有指导意义。

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Effectiveness of CPR in Hypogravity Conditions-A Systematic Review.低重力条件下心肺复苏的有效性——一项系统综述
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