一碳代谢在癌症诊断和治疗方法中的作用。

One-carbon metabolism for cancer diagnostic and therapeutic approaches.

机构信息

Department of Medical Data Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, 565-0871, Japan; Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, 565-0871, Japan; Artificial Intelligence Research Center, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, 567-0047, Japan.

Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, 565-0871, Japan.

出版信息

Cancer Lett. 2020 Feb 1;470:141-148. doi: 10.1016/j.canlet.2019.11.023. Epub 2019 Nov 22.

DOI:10.1016/j.canlet.2019.11.023

PMID:31759958

Abstract

Altered metabolism is critical for the rapid and unregulated proliferation of cancer cells; hence the requirement for an abundant source of nucleotides. One characteristic of this metabolic reprogramming is in one-carbon (1C) metabolism, which is particularly noteworthy for its role in DNA synthesis. Various forms of methylation are also noteworthy as they relate to cancer cell survival and proliferation. In recent years, 1C metabolism has received substantial attention for its role in cancer malignancy via these functions. Therefore, therapeutic inhibitors targeting 1C metabolism have been utilized as anticancer drugs. This review outlines the importance of 1C metabolism and its clinical application in cancer. Understanding 1C metabolism could aid the development of novel cancer diagnostic and therapeutic methods.

摘要

代谢改变对于癌细胞的快速和不受调节的增殖至关重要；因此需要大量的核苷酸来源。这种代谢重编程的一个特征是在一碳（1C）代谢中，其在 DNA 合成中的作用尤为重要。各种形式的甲基化也值得注意，因为它们与癌细胞的存活和增殖有关。近年来，1C 代谢因其在癌症恶性中的这些功能而受到广泛关注。因此，靶向 1C 代谢的治疗抑制剂已被用作抗癌药物。本文概述了 1C 代谢在癌症中的重要性及其临床应用。了解 1C 代谢可能有助于开发新的癌症诊断和治疗方法。