Aatif Mohammad, Raza Muhammad Asam, Javed Khadija, Nashre-Ul-Islam Swah Mohd, Farhan Mohd, Alam Mir Waqas
Department of Public Health, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Chemistry, Hafiz Hayat Campus, University of Gujrat, Gujrat 50700, Pakistan.
Antibiotics (Basel). 2022 Dec 3;11(12):1750. doi: 10.3390/antibiotics11121750.
Heterocyclic compounds are considered as one of the major and most diverse family of organic compounds. Nowadays, the demand for these compounds is increasing day-by-day due to their enormous synthetic and biological applications. These heterocyclic compounds have unique antibacterial activity against various Gram-positive and Gram-negative bacterial strains. This review covers the antibacterial activity of different heterocyclic compounds with nitrogen moiety. Some of the derivatives of these compounds show excellent antibacterial activity, while others show reasonable activity against bacterial strains. This review paper aims to bring and discuss the detailed information on the antibacterial activity of various nitrogen-based heterocyclic compounds. It will be helpful for the future evolution of diseases to synthesize new and effective drug molecules.
杂环化合物被认为是主要且最多样化的有机化合物家族之一。如今,由于其巨大的合成和生物应用,对这些化合物的需求日益增加。这些杂环化合物对各种革兰氏阳性和革兰氏阴性细菌菌株具有独特的抗菌活性。本综述涵盖了含氮杂环化合物的抗菌活性。这些化合物的一些衍生物显示出优异的抗菌活性,而其他衍生物对细菌菌株显示出合理的活性。这篇综述文章旨在带来并讨论各种含氮杂环化合物抗菌活性的详细信息。这将有助于合成新的有效药物分子以应对未来疾病的发展。