Corazziari E, Materia E, Bausano G, Torsoli A, Badiali D, Fanucci A, Fraracci L, Morini S, Capurso L, Montesi A
Cattedra di Gastroenterologia I, Clinica Medica II, Università La Sapienza, Roma, Italy.
J Clin Gastroenterol. 1987 Aug;9(4):427-30. doi: 10.1097/00004836-198708000-00014.
We looked at laxative consumption and its relationship to bowel habits, total gastrointestinal transit time (TGITT), and symptoms in patients with chronic nonorganic constipation. Of the patients, 87.9% used laxative, 30% habitually. Laxative intake increased with age, so that habitual consumption was more frequent in patients with long-standing (greater than 10 years) constipation. Although habitual laxative users had a consistent trend toward lower bowel frequency and prolonged TGITT, no relationship was found among intake and observed bowel frequency, TGITT, or large bowel segmental transit time. Although laxatives induced more satisfactory or less difficult evacuations, they also caused diarrhea and mucus in the stool. Laxative consumption did not bring about any detectable improvement in the abdominal or extraabdominal symptoms usually associated with constipation.
我们研究了慢性非器质性便秘患者的泻药使用情况及其与排便习惯、全胃肠传输时间（TGITT）和症状的关系。在这些患者中，87.9%使用泻药，其中30%为习惯性使用。泻药摄入量随年龄增加，因此在长期（超过10年）便秘患者中习惯性使用更为频繁。尽管习惯性泻药使用者的排便频率有持续降低和TGITT延长的趋势，但未发现泻药摄入量与观察到的排便频率、TGITT或大肠节段传输时间之间存在关联。尽管泻药能使排便更顺畅或难度降低，但也会导致腹泻和大便中出现黏液。泻药的使用并未使通常与便秘相关的腹部或腹部外症状有任何可检测到的改善。
