Badiali D, Marcheggiano A, Pallone F, Paoluzi P, Bausano G, Iannoni C, Materia E, Anzini F, Corazziari E
Dis Colon Rectum. 1985 Apr;28(4):241-5. doi: 10.1007/BF02554044.
In patients with constipation the prevalence of melanosis in rectal biopsies was evaluated in an attempt to correlate its occurrence with laxative consumption and intestinal stasis. Melanosis was present in 58 percent of the patients and in none of a control group. Melanosis was present in 73.4 percent of patients consuming anthracene laxatives and in 26.6 percent of those not consuming anthracene laxatives (P less than 0.01). No correlation was found between the occurrence (and grading) of melanosis and pattern of transit through the large bowel, bowel movements, and duration of symptoms. Results of this study seem to indicate that intestinal stasis is not a cause of melanosis of the colon and rectum and confirm that melanosis may well be due only to the consumption of anthracene laxatives; melanosis coli does not appear to be a sensitive marker of impairment of motor function in the "cathartic colon."
在便秘患者中，对直肠活检中黑变病的患病率进行了评估，旨在将其发生情况与泻药使用及肠道淤滞相关联。58%的患者存在黑变病，而对照组中无一例出现。服用蒽醌类泻药的患者中73.4%存在黑变病，未服用蒽醌类泻药的患者中26.6%存在黑变病（P<0.01）。未发现黑变病的发生（及分级）与通过大肠的转运模式、排便情况及症状持续时间之间存在相关性。本研究结果似乎表明，肠道淤滞并非结肠和直肠黑变病的病因，并证实黑变病很可能仅归因于蒽醌类泻药的使用；结肠黑变病似乎并非“泻药性结肠”运动功能受损的敏感标志物。
