Pop Călin, Gheorghe Fronea Oana Florentina, Branea Ioana Antonia, Itu Lucian Mihai, Darabont Roxana, Parepa Irinel, Benedek Theodora, Dorobantu Maria
Emergency Clinical County Hospital of Baia Mare, 430130 Baia Mare, Romania.
Faculty of Medicine Arad, Str. Feleacului nr. 1, 310414 Arad, Romania.
Diagnostics (Basel). 2022 Dec 16;12(12):3199. doi: 10.3390/diagnostics12123199.
Background: The prevalence of chronic kidney disease (CKD) correlates with the prevalence of hypertension (HT). We studied the prevalence and predictors of CKD in a representative sample of the Romanian adult population. Methods: A sample of 1470 subjects were enrolled in the SEPHAR IV (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk) survey. All subjects were evaluated for blood pressure (BP) and extensive evaluations of target organ damage, blood, and urine samples were undertaken. Results: A total of 883 subjects were included in the statistical analysis. Those experiencing CKD with an eGFR < 60 mL/min/1.73 m2 were older at 71.94 ± 7.4 years (n = 19, 2.15%) compared with those without renal impairment at 50.3 ± 16.21 years (n = 864, 97.85%), p < 0.0001. The prevalence of CKD among hypertensives (379 from 883) was 4.49% (17/379), while 17 out of 19 subjects with CKD had HT (89.47%). After adjusting for age, sex, and diabetic status, only serum uric acid (SUR) > 6.9 mg/dL (OR: 6.61; 95% CI: 2.063, 10.83; p = 0.004) was an independent risk factor and a predictor of CKD. Conclusions: The prevalence of CKD in hypertensive Romanian adults was more than ten times higher than in the normotensive population. Levels of SUR > 6.9 mg/dL were predictors of CKD.
慢性肾脏病（CKD）的患病率与高血压（HT）的患病率相关。我们在罗马尼亚成年人群的代表性样本中研究了CKD的患病率及其预测因素。方法：1470名受试者纳入了SEPHAR IV（高血压与心血管风险患病率评估研究）调查。所有受试者均接受了血压（BP）评估，并对靶器官损害、血液和尿液样本进行了广泛评估。结果：共有883名受试者纳入统计分析。估算肾小球滤过率（eGFR）<60 mL/min/1.73 m² 的CKD患者年龄较大，为71.94±7.4岁（n = 19，2.15%），而无肾功能损害的患者年龄为50.3±16.21岁（n = 864，97.85%），p<0.0001。高血压患者中CKD的患病率（883例中的379例）为4.49%（17/379），而19例CKD患者中有17例患有HT（89.47%）。在调整年龄、性别和糖尿病状态后，仅血清尿酸（SUR）>6.9 mg/dL（OR：6.61；95%CI：2.063，10.83；p = 0.004）是CKD的独立危险因素和预测因素。结论：罗马尼亚高血压成年人群中CKD的患病率比血压正常人群高十多倍。SUR>6.9 mg/dL是CKD的预测因素。
