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有/无认知功能障碍的高血压患者的营养、生活方式习惯与实验室参数之间的关系

Relationship between Nutrition, Lifestyle Habits and Laboratory Parameters in Hypertensive Patients with/without Cognitive Dysfunction.

作者信息

Nyulas Kinga-Ilona, Germán-Salló Márta, Fazakas Zita, Preg Zoltán, Pál Tünde, Pál Sándor, Tripon Robert Gabriel, Cseh Margit Judit, Simon-Szabó Zsuzsánna, Arbănași Emil Marian, Nemes-Nagy Enikő

机构信息

Doctoral School of GE Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, 540136 Târgu Mureş, Romania.

Department of Internal Medicine II, Faculty of Medicine, GE Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, 540136 Târgu Mureş, Romania.

出版信息

Life (Basel). 2023 Jan 22;13(2):311. doi: 10.3390/life13020311.

Abstract

UNLABELLED

(1) Background: Cognitive dysfunction is a major concern in hypertensive patients. Lifestyle habits and nutrition influence laboratory parameters, with an impact on clinical course. The objective of the study was to evaluate nutrition and lifestyle habits in hypertensive patients with/without cognitive dysfunction and establish correlations to laboratory parameters.

MATERIAL AND METHODS

50 patients admitted to the Cardiovascular Rehabilitation Clinic in Târgu Mureș were enrolled in this study between March-June 2021. We evaluated their cognitive function, and they filled in a questionnaire about lifestyle and nutrition. Biochemical blood tests were performed using a Konelab Prime 60i analyzer. IBM-SPSS22 and GraphPad InStat3 were used for statistics.

RESULTS

Mean age of hypertensive patients (n = 50) was 70.42 ± 4.82 (SD) years, half of them had cognitive dysfunction. Zinc deficiency was present in 74% of the subjects. The subgroup with cognitive dysfunction had significantly higher BMI ( = 0.009) and microalbuminuria ( = 0.0479), as well as significantly lower magnesium intake ( = 0.032) and cholesterol intake ( = 0.022), compared to those with normal cognitive status.

CONCLUSIONS

Nutrition is in a close relationship with laboratory parameters; significant differences (microalbuminuria, cholesterol intake, BMI, etc.) are present between hypertensive patients with/without cognitive dysfunction. A healthy diet is important for the maintenance of metabolic balance, the achievement of optimal body weight, and the prevention of complications.

摘要

未标注

(1)背景:认知功能障碍是高血压患者的一个主要问题。生活方式习惯和营养会影响实验室参数,进而影响临床病程。本研究的目的是评估有/无认知功能障碍的高血压患者的营养和生活方式习惯,并建立与实验室参数的相关性。

材料与方法

2021年3月至6月期间,招募了50名入住特尔古穆列什心血管康复诊所的患者参与本研究。我们评估了他们的认知功能,并让他们填写了一份关于生活方式和营养的问卷。使用科耐立Prime 60i分析仪进行血液生化检测。使用IBM-SPSS22和GraphPad InStat3进行统计分析。

结果

高血压患者(n = 50)的平均年龄为70.42 ± 4.82(标准差)岁,其中一半有认知功能障碍。74%的受试者存在锌缺乏。与认知状态正常的患者相比,有认知功能障碍的亚组的体重指数(P = 0.009)和微量白蛋白尿(P = 0.0479)显著更高,而镁摄入量(P = 0.032)和胆固醇摄入量(P = 0.022)显著更低。

结论

营养与实验室参数密切相关;有/无认知功能障碍的高血压患者之间存在显著差异(微量白蛋白尿、胆固醇摄入量、体重指数等)。健康饮食对于维持代谢平衡、实现最佳体重和预防并发症很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d526/9960921/383e5bc33894/life-13-00311-g001.jpg

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