Department of Hematology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230032, China.
Department of Respiratory, Wannan Medical College, Wuhu 241002, China.
Int J Environ Res Public Health. 2022 Dec 8;19(24):16475. doi: 10.3390/ijerph192416475.
Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter water bodies, affecting human health. Water pollutants contain a vast number of additives, such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metals, and pharmacologies. In this work, we aim to explore the potential relationship between water pollutants and human diseases. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to many diseases, including colonic neoplasms, breast neoplasms, hepatitis B, bladder cancer, and human cytomegalovirus infection. In addition, further analysis revealed the genes that play a key role in the human diseases induced by water pollutants. Therefore, conducting an integrative toxicogenomic analysis of water pollutants is more appropriate for evaluating the potential effects of water pollutants on human health.
饮用水是一种重要的自然资源。对于世界上许多人来说，特别是在发展中国家，获得安全饮用水仍然是一个梦想。越来越多的人类活动和工业化导致各种物理、化学和生物污染物进入水体，影响人类健康。水污染中含有大量的添加剂，如全氟化合物、多溴联苯醚、邻苯二甲酸酯、纳米材料、杀虫剂、微囊藻毒素、重金属和药理学物质。在这项工作中，我们旨在探讨水污染物与人类疾病之间的潜在关系。在这里，我们探索了一种综合方法，以识别与接触这些水污染物相关的基因、生物过程、分子功能和疾病。这些受水污染影响的过程和功能与许多疾病有关，包括结肠肿瘤、乳腺肿瘤、乙型肝炎、膀胱癌和人巨细胞病毒感染。此外，进一步的分析揭示了在水污染引起的人类疾病中起关键作用的基因。因此，对水污染物进行综合毒代基因组学分析更适合评估水污染物对人类健康的潜在影响。
