Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Int J Mol Sci. 2022 Dec 9;23(24):15627. doi: 10.3390/ijms232415627.
Lifestyle changes have led to increased incidence of cardiovascular disease (CVD); therefore, potential targets against CVD should be explored to mitigate its risks. Adiponectin (APN), an adipokine secreted by adipose tissue, has numerous beneficial effects against CVD related to glucose and lipid metabolism disorders, including regulation of glucose and lipid metabolism, increasing insulin sensitivity, reduction of oxidative stress and inflammation, protection of myocardial cells, and improvement in endothelial cell function. These effects demonstrate the anti-atherosclerotic and antihypertensive properties of APN, which could aid in improving myocardial hypertrophy, and reducing myocardial ischemia/reperfusion (MI/R) injury and myocardial infarction. APN can also be used for diagnosing and predicting heart failure. This review summarizes and discusses the role of APN in the treatment of CVD related to glucose and lipid metabolism disorders, and explores future APN research directions and clinical application prospects. Future studies should elucidate the signaling pathway network of APN cardiovascular protective effects, which will facilitate clinical trials targeting APN for CVD treatment in a clinical setting.
生活方式的改变导致心血管疾病 (CVD) 的发病率增加；因此，应该探索针对 CVD 的潜在靶点，以降低其风险。脂联素 (APN) 是脂肪组织分泌的一种脂肪因子，对与葡萄糖和脂质代谢紊乱相关的 CVD 具有多种有益作用，包括调节葡萄糖和脂质代谢、增加胰岛素敏感性、减少氧化应激和炎症、保护心肌细胞以及改善内皮细胞功能。这些作用表明 APN 具有抗动脉粥样硬化和降压作用，有助于改善心肌肥厚，减少心肌缺血/再灌注 (MI/R) 损伤和心肌梗死。APN 还可用于诊断和预测心力衰竭。本综述总结并讨论了 APN 在治疗与葡萄糖和脂质代谢紊乱相关的 CVD 中的作用，并探讨了未来 APN 的研究方向和临床应用前景。未来的研究应该阐明 APN 心血管保护作用的信号通路网络，这将有助于针对 CVD 治疗的 APN 临床试验在临床环境中的开展。
