Roy Bipradas, Palaniyandi Suresh Selvaraj
Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Integrative Biosciences Center (IBio), Room #3402, 6135 Woodward, Detroit, MI, 48202, USA.
Department of Physiology, Wayne State University, Detroit, MI, 48202, USA.
Cell Biosci. 2021 Apr 26;11(1):77. doi: 10.1186/s13578-021-00587-4.
According to the World Health Organization, metabolic syndrome (MetS) can be defined as a pathological condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. The incidence of MetS keeps rising, as at least 35% of the USA population suffers from MetS. One of the worst comorbidities of metabolic syndrome are cardiovascular diseases that significantly amplifies the mortality associated with this syndrome. There is an urgent need to understand the pathophysiology of MetS to find novel diagnosis, treatment and management to mitigate the MetS and associated complications. Altered circulatory adiponectin levels have been implicated in MetS. Adiponectin has numerous biologic functions including antioxidative, anti-nitrative, anti-inflammatory, and cardioprotective effects. Being a pleiotropic hormone of multiple tissues, tissue-specific key signaling pathways of adiponectin will help finding specific target/s to blunt the pathophysiology of metabolic syndrome and associated disorders. The purpose of this review is to elucidate tissue-specific signaling pathways of adiponectin and possibly identify potential therapeutic targets for MetS as well as to evaluate the potential of adiponectin as a biomarker/therapeutic option in MetS.
根据世界卫生组织的定义，代谢综合征（MetS）可被界定为一种以腹部肥胖、胰岛素抵抗、高血压和高脂血症为特征的病理状态。代谢综合征的发病率持续上升，美国至少35%的人口患有代谢综合征。代谢综合征最严重的合并症之一是心血管疾病，它显著增加了与该综合征相关的死亡率。迫切需要了解代谢综合征的病理生理学，以寻找新的诊断、治疗和管理方法，减轻代谢综合征及其相关并发症。循环脂联素水平的改变与代谢综合征有关。脂联素具有多种生物学功能，包括抗氧化、抗硝化、抗炎和心脏保护作用。作为一种多组织的多效性激素，脂联素的组织特异性关键信号通路将有助于找到特定靶点，以抑制代谢综合征及相关疾病的病理生理学。本综述的目的是阐明脂联素的组织特异性信号通路，可能确定代谢综合征的潜在治疗靶点，并评估脂联素作为代谢综合征生物标志物/治疗选择的潜力。
