Khlynov Ruslan D, Ryzhova Victoria A, Yarishev Sergey N, Konyakhin Igor A, Korotaev Valery V, Shelepin Yuri E, Djamiykov Todor S, Marinov Marin B
Applied Optic Centre, ITMO University, Kronverksky Pr. 49, Bldg. A, 197101 St. Petersburg, Russia.
School of Physics and Engineering, ITMO University, Kronverksky Pr. 49, Bldg. A, 197101 St. Petersburg, Russia.
Micromachines (Basel). 2022 Dec 16;13(12):2241. doi: 10.3390/mi13122241.
The development of non-invasive optoelectronic technologies for human blood monitoring is one of the important research areas for medicine. A critical analysis of optoelectronic methods of blood research and the micromechanical systems based on them is carried out in this article. A design realization of a polarizing portable system for non-invasive monitoring of hematocrit as one of the basic homeostatic constants of the human body containing information about the microphysical parameters of blood cells has been substantiated. A physical model of polarized radiation conversion in a video information system of laser sensing of a biological research object has been formed. Visual and quantitative differences in the spatial distribution of polarization parameters of the scattered radiation for the states of the body with different hematocrit levels have been revealed. A scheme of a multichannel imaging portable system, based on a smartphone using miniature optical and microelectronic components of information conversion for non-invasive monitoring of microphysical blood parameters, has been created. The system implements the principle of polarimetric blood photometry and a multiparametric analysis of the polarization properties of the laser radiation scattered by blood. The developed portable optoelectronic system, based on a smartphone, can be used for rapid blood diagnostics in disaster medicine and the presence of clinical contraindications to the formation of invasive tests. The proposed polarization-based approach is a promising automated alternative to traditional devices and systems for the research of microphysical blood parameters.
用于人体血液监测的非侵入式光电技术的发展是医学重要的研究领域之一。本文对血液研究的光电方法及其基于此的微机械系统进行了批判性分析。论证了一种用于无创监测血细胞比容的偏振便携式系统的设计实现，血细胞比容是人体基本的稳态常数之一，包含有关血细胞微观物理参数的信息。建立了生物研究对象激光传感视频信息系统中偏振辐射转换的物理模型。揭示了不同血细胞比容水平的人体状态下散射辐射偏振参数空间分布的视觉和定量差异。创建了一种基于智能手机的多通道成像便携式系统方案，该系统使用微型光学和微电子信息转换组件来无创监测血液微观物理参数。该系统实现了偏振血液光度测定原理以及对血液散射激光辐射偏振特性的多参数分析。所开发的基于智能手机的便携式光电系统可用于灾害医学中的快速血液诊断以及存在侵入性检测临床禁忌的情况。所提出的基于偏振的方法是用于研究血液微观物理参数的传统设备和系统的一种有前景的自动化替代方案。
