Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Molecules. 2022 Dec 13;27(24):8848. doi: 10.3390/molecules27248848.
Polymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and maleic acid (PVM/MA). Samples were tested for mechanical properties (surface hardness, flexural strength, water sorption, and water solubility) and effects against Streptococcus mutans. Six groups (0%-control, 5%, 10%, 15%, 20%, and 25% Gantrez) of n = 12 were fabricated for physical property tests and analyzed with one-way ANOVA and Prism 6. From these results, three groups (0%, 5%, and 10% Gantrez) were selected for antibacterial tests, and data were analyzed with one-way ANOVA and Tukey’s multiple comparison test. Adding 5% and 10% Gantrez into PMMA significantly decreased S. mutans adhesion. There was no significant difference between the control vs. 5%, 10%, 15%, and 20% Gantrez (p > 0.05) for surface hardness, the control vs. 5% Gantrez (p > 0.05) for flexural strength, and the control vs. 5 and 10% Gantrez for water sorption and water solubility. Overall, incorporating 5% Gantrez into PMMA may be a promising solution to reduce bacterial adhesion without changing the acrylic resin’s physical properties.
聚甲基丙烯酸甲酯（PMMA）是一种用于正畸器具和可摘义齿的丙烯酸树脂，因其生物相容性和美观性而被使用，其表面可能带有细菌。本研究调查了一种新的 PMMA 配方，其中含有 Gantrez：甲基乙烯基醚和马来酸的抗菌共聚物（PVM/MA）。对样品进行了机械性能（表面硬度、弯曲强度、吸水率和水溶性）和对变形链球菌影响的测试。制作了 6 组（0%-对照、5%、10%、15%、20%和 25%Gantrez）n = 12 的样本，用于物理性能测试，并使用单因素方差分析和 Prism 6 进行分析。根据这些结果，选择了三组（0%、5%和 10%Gantrez）进行抗菌测试，并使用单因素方差分析和 Tukey 的多重比较测试进行数据分析。在 PMMA 中添加 5%和 10%Gantrez 显著降低了变形链球菌的粘附。对照组与 5%、10%、15%和 20%Gantrez 之间的表面硬度无显著差异（p > 0.05），对照组与 5%Gantrez 之间的弯曲强度无显著差异（p > 0.05），对照组与 5%和 10%Gantrez 之间的吸水率和水溶性无显著差异（p > 0.05）。总体而言，在 PMMA 中加入 5%Gantrez 可能是一种有前途的解决方案，可以减少细菌粘附，而不会改变丙烯酸树脂的物理性能。
