Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51542, Saudi Arabia.
Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51542, Saudi Arabia.
Molecules. 2022 Dec 17;27(24):9009. doi: 10.3390/molecules27249009.
Cancer is a main culprit and the second-leading cause of death worldwide. The current mode of treatment strategies including surgery with chemotherapy and radiation therapy may be effective, but cancer is still considered a major cause of death. Plant-derived products or their purified bioactive compounds have confirmed health-promoting effects as well as cancer-preventive effects. Among these products, flavonoids belong to polyphenols, chiefly found in fruits, vegetables and in various seeds/flowers. It has been considered to be an effective antioxidant, anti-inflammatory and to play a vital role in diseases management. Besides these activities, flavonoids have been revealed to possess anticancer potential through the modulation of various cell signaling molecules. In this regard, fisetin, a naturally occurring flavonoid, has a confirmed role in disease management through antioxidant, neuro-protective, anti-diabetic, hepato-protective and reno-protective potential. As well, its cancer-preventive effects have been confirmed via modulating various cell signaling pathways including inflammation, apoptosis, angiogenesis, growth factor, transcription factor and other cell signaling pathways. This review presents an overview of the anti-cancer potential of fisetin in different types of cancer through the modulation of cell signaling pathways based on in vivo and in vitro studies. A synergistic effect with anticancer drugs and strategies to improve the bioavailability are described. More clinical trials need to be performed to explore the anti-cancer potential and mechanism-of-action of fisetin and its optimum therapeutic dose.
癌症是全球主要的罪魁祸首和第二大死亡原因。目前的治疗策略包括手术结合化疗和放疗可能有效，但癌症仍然是主要的死亡原因。植物来源的产品或其纯化的生物活性化合物已被证实具有促进健康和预防癌症的作用。在这些产品中，类黄酮属于多酚，主要存在于水果、蔬菜和各种种子/花中。它被认为是一种有效的抗氧化剂、抗炎剂，在疾病管理中起着至关重要的作用。除了这些活性外，类黄酮还通过调节各种细胞信号分子显示出抗癌潜力。在这方面，漆树黄酮是一种天然存在的类黄酮，通过抗氧化、神经保护、抗糖尿病、肝保护和肾保护作用，在疾病管理中发挥着明确的作用。此外，通过调节炎症、细胞凋亡、血管生成、生长因子、转录因子和其他细胞信号通路等多种细胞信号通路，证实了其具有预防癌症的作用。本综述根据体内和体外研究，概述了漆树黄酮通过调节细胞信号通路在不同类型癌症中的抗癌潜力。描述了与抗癌药物的协同作用以及提高生物利用度的策略。需要进行更多的临床试验来探索漆树黄酮的抗癌潜力和作用机制及其最佳治疗剂量。
