Seggio Mimimorena, Laneri Francesca, Graziano Adriana C E, Natile Marta Maria, Fraix Aurore, Sortino Salvatore
PhotoChemLab, Department of Drug and Health Sciences, University of Catania, 95124 Catania, Italy.
ICMATE-CNR Institute of Condensed Matter Chemistry and Technologies for Energy, National Research Council, Department of Chemical Science, University of Padova, 35131 Padova, Italy.
Nanomaterials (Basel). 2022 Dec 17;12(24):4476. doi: 10.3390/nano12244476.
Au nanostructures exhibiting a localized surface plasmon resonance in the near-infrared spectral window are obtained in a single, green step at room temperature by pomegranate extract in the presence of a highly biocompatible β-cyclodextrin branched polymer, without the need of preformed seeds, external reducing and sacrificial agents, and conventional surfactants. The polymeric component makes the Au nanostructures dispersible in water, stable for weeks and permits their supramolecular assembling with the chemotherapeutic sorafenib and a nitric oxide (NO) photodonor (NOPD), chosen as representative for chemo- and photo-therapeutics. Irradiation of the plasmonic Au nanostructures in the therapeutic window with 808 nm laser light results in a good photothermal response, which (i) is not affected by the presence of either the chemo- or the phototherapeutic guests and (ii) does not lead to their photoinduced decomposition. Besides, irradiation of the hybrid Au nanoassembly with the highly biocompatible green light results in the NO release from the NOPD with efficiency similar to that observed for the free guest. Preliminary biological experiments against Hep-G2 hepatocarcinoma cell lines are also reported.
在室温下，通过石榴提取物在具有高度生物相容性的β-环糊精支化聚合物存在下，以单一的绿色步骤获得了在近红外光谱窗口中表现出局域表面等离子体共振的金纳米结构，无需预先形成的种子、外部还原剂和牺牲剂以及传统表面活性剂。聚合物成分使金纳米结构可分散在水中，稳定数周，并允许它们与化疗药物索拉非尼和一氧化氮（NO）光供体（NOPD）进行超分子组装，NOPD被选作化学疗法和光疗法的代表。用808nm激光照射治疗窗口中的等离子体金纳米结构会产生良好的光热响应，该响应（i）不受化学治疗或光治疗客体存在的影响，并且（ii）不会导致它们的光致分解。此外，用高度生物相容性的绿光照射杂化金纳米组装体可导致NOPD释放NO，其效率与游离客体观察到的效率相似。还报道了针对Hep-G2肝癌细胞系的初步生物学实验。
