二氧化铈-氮杂冠醚共轭物作为联合放射性药物的纳米平台

CeO-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals.

作者信息

Khabirova Sofia, Aleshin Gleb, Plakhova Tatiana, Zubenko Anastasia, Shchukina Anna, Fedorova Olga, Averin Aleksey, Belova Ekaterina, Bazarkina Elena, Kvashnina Kristina, Kalmykov Stepan

机构信息

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia.

N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia.

出版信息

Nanomaterials (Basel). 2022 Dec 18;12(24):4484. doi: 10.3390/nano12244484.

This study is one of the first attempts to assess CeO nanoparticles as a nanoplatform for radiopharmaceuticals with radionuclides. The process of functionalization using a bifunctional azacrown ligand is described, and the resulting conjugates are characterized by IR and Raman spectroscopy. Their complexes with Bi show a high stability in medically relevant media, thus encouraging the further study of these conjugates in vivo as potential combined radiopharmaceuticals.