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维生素 C 对长期过量碘暴露致 Wistar 大鼠氧化损伤的保护作用。

Protection of Vitamin C on Oxidative Damage Caused by Long-Term Excess Iodine Exposure in Wistar Rats.

机构信息

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China.

Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province (23618504), Ministry of Health, Microelement and Human Health Lab of Heilongjiang Province, Harbin 150081, China.

出版信息

Nutrients. 2022 Dec 9;14(24):5245. doi: 10.3390/nu14245245.

DOI:10.3390/nu14245245
PMID:36558407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9786336/
Abstract

Vitamin C was reported to be able to protect against oxidative damage due to its reducibility. 120 Wistar rats were randomly divided into 4 × 2 groups, including normal iodine (NI), high iodine (HI), low vitamin C (HI + LC), and high vitamin C (HI + HC); potassium iodide (KI) and potassium iodate (KIO) were commonly used as additives for iodized salt, so every group was also divided into KI and KIO groups. After 6 months' feed, the activities of antioxidant enzymes and Lipid Peroxide (MDA) content in serum, liver, kidney, brain, thyroid and lens were determined. In serum, for males, long-term excess iodine intake caused oxidative damage; in the liver, male rats in the HI + LC group had the highest MDA content, which showed that low-dose vitamin C might promote oxidative damage; in kidneys, the MDA content in the HI and HI + LC groups of females was higher; in the brain, high-dose vitamin C could increase the activity of superoxide dismutase (SOD), which was decreased by high iodine intake, and it also decreased MDA content; in the thyroid, for KIO, the activity of SOD in the HI group was lower than NI and HI + LC; in the lens, the MDA content in females was lower than males. Long-term excess iodine exposure caused oxidative damage and showed sex difference, and vitamin C had a protective effect on it, especially for high-dose vitamin C.

摘要

维生素 C 因其还原性而被报道能够防止氧化损伤。120 只 Wistar 大鼠被随机分为 4×2 组，包括正常碘（NI）、高碘（HI）、低维生素 C（HI+LC）和高维生素 C（HI+HC）；碘化钾（KI）和碘酸钾（KIO）通常被用作加碘盐的添加剂，因此每组还分为 KI 和 KIO 组。经过 6 个月的喂养，测定了血清、肝、肾、脑、甲状腺和晶状体中抗氧化酶的活性和脂质过氧化物（MDA）含量。在血清中，对于男性，长期过量摄入碘会导致氧化损伤；在肝脏中，HI+LC 组雄性大鼠的 MDA 含量最高，表明低剂量维生素 C 可能会促进氧化损伤；在肾脏中，HI 和 HI+LC 组雌性大鼠的 MDA 含量较高；在大脑中，高剂量维生素 C 可以增加超氧化物歧化酶（SOD）的活性，而高碘摄入会降低 SOD 的活性，同时也降低 MDA 含量；在甲状腺中，对于 KIO，HI 组的 SOD 活性低于 NI 和 HI+LC；在晶状体中，女性的 MDA 含量低于男性。长期过量的碘暴露会导致氧化损伤，并表现出性别差异，而维生素 C 对其具有保护作用，特别是高剂量的维生素 C。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/ecb6830fec01/nutrients-14-05245-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/292ae3bf89bf/nutrients-14-05245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/ab9010de07fe/nutrients-14-05245-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/c7957d237706/nutrients-14-05245-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/ecb6830fec01/nutrients-14-05245-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/292ae3bf89bf/nutrients-14-05245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/ab9010de07fe/nutrients-14-05245-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/c7957d237706/nutrients-14-05245-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac98/9786336/d40563ea189f/nutrients-14-05245-g004.jpg
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