Lajoie Léo, Fabiano-Tixier Anne-Sylvie, Chemat Farid
Groupe de Recherche en Eco-Extraction de Produits Naturel, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Unité Mixte de Recherche 408, Département Agrosciences, Faculté de Chimie, Avignon Université, F-84000 Avignon, France.
Pharmaceuticals (Basel). 2022 Dec 3;15(12):1507. doi: 10.3390/ph15121507.
Water is considered the greenest solvent. Nonetheless, the water solubility of natural products is still an incredibly challenging issue. Indeed, it is nearly impossible to solubilize or to extract many natural products properly using solely water due to their low solubility in this solvent. To address this issue, researchers have tried for decades to tune water properties to enhance its solvent potential in order to be able to solubilise or extract low-water solubility compounds. A few methods involving the use of solubilisers were described in the early 2000s. Since then, and particularly in recent years, additional methods have been described as useful to ensure the effective green extraction but also solubilisation of natural products using water as a solvent. Notably, combinations of these green methods unlock even higher extraction performances. This review aims to present, compare and analyse all promising methods and their relevant combinations to extract natural products from bioresources with water as solvent enhanced by green solubilisers and/or processes.
水被认为是最绿色的溶剂。尽管如此，天然产物的水溶性仍然是一个极具挑战性的问题。事实上，由于许多天然产物在水中的溶解度很低，仅用水几乎不可能将其充分溶解或提取出来。为了解决这个问题，几十年来，研究人员一直试图调整水的性质，以增强其溶剂潜力，从而能够溶解或提取低水溶性化合物。21世纪初描述了一些使用增溶剂的方法。从那时起，特别是近年来，又有其他方法被描述为有助于确保使用水作为溶剂对天然产物进行有效的绿色提取和溶解。值得注意的是，这些绿色方法的组合能实现更高的提取性能。这篇综述旨在介绍、比较和分析所有有前景的方法及其相关组合，以便在绿色增溶剂和/或工艺的辅助下，以水为溶剂从生物资源中提取天然产物。
