Pawar Bhakti, Vasdev Nupur, Gupta Tanisha, Mhatre Mahi, More Anand, Anup Neelima, Tekade Rakesh Kumar
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Opposite Air Force Station Palaj, Gandhinagar 382355, Gujarat, India.
Pharmaceutics. 2022 Dec 5;14(12):2719. doi: 10.3390/pharmaceutics14122719.
It is well known that the presence of a blood-brain barrier (BBB) makes drug delivery to the brain more challenging. There are various mechanistic routes through which therapeutic molecules travel and deliver the drug across the BBB. Among all the routes, the transcellular route is widely explored to deliver therapeutics. Advances in nanotechnology have encouraged scientists to develop novel formulations for brain drug delivery. In this article, we have broadly discussed the BBB as a limitation for brain drug delivery and ways to solve it using novel techniques such as nanomedicine, nose-to-brain drug delivery, and peptide as a drug delivery carrier. In addition, the article will help to understand the different factors governing the permeability of the BBB, as well as various formulation-related factors and the body clearance of the drug delivered into the brain.
众所周知，血脑屏障（BBB）的存在使药物向大脑的递送更具挑战性。治疗性分子通过各种机制途径穿过血脑屏障并递送药物。在所有途径中，跨细胞途径被广泛研究用于递送治疗药物。纳米技术的进展促使科学家开发用于脑内药物递送的新型制剂。在本文中，我们广泛讨论了血脑屏障作为脑内药物递送的限制因素，以及使用纳米医学、鼻脑给药和肽作为药物递送载体等新技术来解决这一问题的方法。此外，本文将有助于理解影响血脑屏障通透性的不同因素，以及各种与制剂相关的因素和递送至脑内的药物的体内清除情况。
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