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Noncanonical Amino Acids in Biocatalysis.
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Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols.
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Residue-Specific Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts:
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Chemical Process Development in the Pharmaceutical Industry in Europe-Insights and Perspectives from Industry Scientists.
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Biocatalytic Synthesis of α-Amino Esters via Nitrene C-H Insertion.
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Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis.
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Continuous flow synthesis enabling reaction discovery.
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Molecular and Structural Basis for Cγ-C Bond Formation by PLP-Dependent Enzyme Fub7.
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Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery.
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Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction.
Nat Catal. 2022 Feb;5(2):136-143. doi: 10.1038/s41929-022-00743-0. Epub 2022 Feb 21.
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Site-Selective Deuteration of Amino Acids through Dual-Protein Catalysis.
J Am Chem Soc. 2022 Apr 27;144(16):7327-7336. doi: 10.1021/jacs.2c00608. Epub 2022 Apr 13.
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Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement.
J Am Chem Soc. 2022 Mar 23;144(11):4739-4745. doi: 10.1021/jacs.2c00251. Epub 2022 Mar 8.
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Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors.
J Am Chem Soc. 2022 Feb 16;144(6):2590-2602. doi: 10.1021/jacs.1c10750. Epub 2022 Feb 2.
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β-NAD as a building block in natural product biosynthesis.
Nature. 2021 Dec;600(7890):754-758. doi: 10.1038/s41586-021-04214-7. Epub 2021 Dec 8.
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An oral SARS-CoV-2 M inhibitor clinical candidate for the treatment of COVID-19.
Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2.
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A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem. 2021 Nov 25;64(22):16770-16800. doi: 10.1021/acs.jmedchem.1c01599. Epub 2021 Oct 27.
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Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation.
Nat Chem. 2021 Dec;13(12):1166-1172. doi: 10.1038/s41557-021-00794-z. Epub 2021 Oct 18.
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Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters.
ACS Catal. 2020 Jul 2;10(13):7413-7418. doi: 10.1021/acscatal.0c01885. Epub 2020 Jun 23.
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Directed Evolution: Methodologies and Applications.
Chem Rev. 2021 Oct 27;121(20):12384-12444. doi: 10.1021/acs.chemrev.1c00260. Epub 2021 Jul 23.

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