Division of Chemistry and Chemical Engineering, 210-41, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, United States.
Division of Chemistry and Chemical Engineering, 210-41, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, United States.
Curr Opin Chem Biol. 2024 Dec;83:102536. doi: 10.1016/j.cbpa.2024.102536. Epub 2024 Oct 5.
Biocatalysis has the potential to address the need for more sustainable organic synthesis routes. Protein engineering can tune enzymes to perform in cascade reactions and for efficient synthesis of enantiomerically enriched compounds, using both natural and new-to-nature reaction pathways. This review highlights recent achievements in biocatalysis, especially the development of novel enzymatic syntheses to access versatile small molecule intermediates and complex biomolecules. Biocatalytic strategies for the degradation of persistent pollutants and approaches for biomass valorization are also discussed. The transition of chemical synthesis to a greener future will be accelerated by implementing enzymes and engineering them for high performance and new activities.
生物催化有可能满足对更可持续的有机合成路线的需求。通过蛋白质工程，酶可以被调谐以进行级联反应，并使用天然和新的非天然反应途径高效合成对映体富集的化合物。本综述重点介绍了生物催化的最新成就，特别是开发新型酶促合成方法以获得多功能小分子中间体和复杂生物分子。还讨论了生物催化策略用于降解持久性污染物和生物质增值的方法。通过实施酶并对其进行工程设计以实现高性能和新活性，将加速化学合成向更绿色未来的转变。
