LINC00152在不同疾病中的作用综述。
A review on the role of LINC00152 in different disorders.
作者信息
Ghafouri-Fard Soudeh, Askari Arian, Hussen Bashdar Mahmud, Rasul Mohammed Fatih, Taheri Mohammad, Kiani Arda
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Pathol Res Pract. 2023 Jan;241:154274. doi: 10.1016/j.prp.2022.154274. Epub 2022 Dec 13.
LINC00152 is an important lncRNA in human disorders. It is mainly regarded as a tumor-promoting lncRNA. Mechanistically, LINC00152 serves as a molecular sponge for miR-143a-3p, miR-125a-5p, miR-139, miR-215, miR-193a/b-3p, miR-16-5p, miR-206, miR-195, miR-138, miR-185-5p, miR-103, miR-612, miR-150, miR-107, miR-205-5p and miR-153-3p. In addition, it can regulate activity of mTOR, EGFR/PI3K/AKT, ERK/MAPK, Wnt/β-Catenin, EGFR, NF-κB, HIF-1 and PTEN. In this review, we provide a concise but comprehensive explanation about the role of LINC00152 in tumor development and progression as well as its role in the pathology of non-malignant conditions with the aim of facilitating the clinical implementation of this lncRNA as a diagnostic or prognostic tumor marker and therapeutic target.
LINC00152是人类疾病中一种重要的长链非编码RNA。它主要被视为一种促肿瘤的长链非编码RNA。从机制上讲，LINC00152作为miR-143a-3p、miR-125a-5p、miR-139、miR-215、miR-193a/b-3p、miR-16-5p、miR-206、miR-195、miR-138、miR-185-5p、miR-103、miR-612、miR-150、miR-107、miR-205-5p和miR-153-3p的分子海绵。此外，它还可以调节mTOR、EGFR/PI3K/AKT、ERK/MAPK、Wnt/β-连环蛋白、EGFR、NF-κB、HIF-1和PTEN的活性。在这篇综述中，我们简要而全面地解释了LINC00152在肿瘤发生发展中的作用及其在非恶性疾病病理中的作用，目的是促进将这种长链非编码RNA作为诊断或预后肿瘤标志物及治疗靶点的临床应用。
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