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交织聚醚醚酮复合支架的制备与性能。

Fabrication and properties of interweaved poly(ether ether ketone) composite scaffolds.

机构信息

School of Electromechanical Engineering, Guilin University of Aerospace Technology, Guilin, 541004, China.

Byd Precicion Manufacture Corporation Limited, Shenzhen, 518000, China.

出版信息

Sci Rep. 2022 Dec 23;12(1):22193. doi: 10.1038/s41598-022-26736-4.

DOI:10.1038/s41598-022-26736-4
PMID:36564487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9789044/
Abstract

This paper interweaved scaffolds with poly(ether ether ketone) (PEEK) and poly(lactic acid)/Walnut shell/hydroxypatite (PLA/WS/HA) composites by using fused filament fabrication technology, although there was a huge difference in thermal property term between PLA and PEEK. In order to keep mechanical properties of PEEK scaffold and remedy the stress loss produced by pores, PLA/WS/HA composites were used to fill the pores with gradient form outside-in (0.4-0.8 mm, 0.6-1.0 mm, 0.8-1.2 mm and 1.6-2.0 mm). The thermal stability, tensile and compression properties, tensile fracture surface morphology, cytotoxicity and in vivo experiment were investigated. The results showed: the scaffolds were intact without any flashes and surface destruction, and kept a well thermal stability. Compared with the PEEK porous scaffolds, the tensile fracture stress and strain, compression yield stress and strain of interweaved scaffolds were dramatically enhanced by 24.1%, 438%, 359.1% and 921.2%, respectively, and they climbed to the climax at 8 wt% of WS. In vivo experiment showed that the degradation of PLA/WS/HA composites synchronized with the adhesion, proliferation and ingrowth of bone cells, keeping the stable biomechanical properties of interweaved scaffolds. Those experiments showed that interweaved PEEK-PLA/WS/HA scaffolds had the potential to be used as bone implant in tissue engineering.

摘要

本文采用熔融沉积成型技术将支架与聚醚醚酮（PEEK）和聚乳酸/核桃壳/羟基磷灰石（PLA/WS/HA）复合材料交织在一起，尽管 PLA 和 PEEK 的热性能参数存在巨大差异。为了保持 PEEK 支架的机械性能并弥补孔隙产生的应力损失，采用 PLA/WS/HA 复合材料以由外向内的梯度形式填充孔隙（0.4-0.8mm、0.6-1.0mm、0.8-1.2mm 和 1.6-2.0mm）。研究了热稳定性、拉伸和压缩性能、拉伸断裂表面形貌、细胞毒性和体内实验。结果表明：支架完整，无任何闪光和表面破坏，保持良好的热稳定性。与 PEEK 多孔支架相比，交织支架的拉伸断裂应力和应变、压缩屈服应力和应变分别显著提高了 24.1%、438%、359.1%和 921.2%，在 WS 含量为 8wt%时达到峰值。体内实验表明，PLA/WS/HA 复合材料的降解与骨细胞的黏附、增殖和长入同步进行，保持交织支架稳定的生物力学性能。这些实验表明，交织的 PEEK-PLA/WS/HA 支架具有作为组织工程中骨植入物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/6f92b847461d/41598_2022_26736_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/99119c00cc08/41598_2022_26736_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/e353d8fe2af5/41598_2022_26736_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/f4e4773958e6/41598_2022_26736_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/ab0304054c74/41598_2022_26736_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/6c717db3660c/41598_2022_26736_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/87b85f7efe15/41598_2022_26736_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/25e5e21868cf/41598_2022_26736_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/59c9f479c8f5/41598_2022_26736_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/aee910fcf734/41598_2022_26736_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/fa93616f06a3/41598_2022_26736_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/90bf071b9d58/41598_2022_26736_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/804a524dcd64/41598_2022_26736_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/7ce4180e63c1/41598_2022_26736_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/489df4bb0497/41598_2022_26736_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/7f28ed343db8/41598_2022_26736_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/6f92b847461d/41598_2022_26736_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/99119c00cc08/41598_2022_26736_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/e353d8fe2af5/41598_2022_26736_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/f4e4773958e6/41598_2022_26736_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/ab0304054c74/41598_2022_26736_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/6c717db3660c/41598_2022_26736_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/87b85f7efe15/41598_2022_26736_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/25e5e21868cf/41598_2022_26736_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/59c9f479c8f5/41598_2022_26736_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/aee910fcf734/41598_2022_26736_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/fa93616f06a3/41598_2022_26736_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/90bf071b9d58/41598_2022_26736_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/804a524dcd64/41598_2022_26736_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/7ce4180e63c1/41598_2022_26736_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/489df4bb0497/41598_2022_26736_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/7f28ed343db8/41598_2022_26736_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c4/9789044/6f92b847461d/41598_2022_26736_Fig16_HTML.jpg

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