Reutov V P, Davydova L A, Sorokina E G
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Belarusian State Medical University, 220116 Minsk, Belarus.
Biophysics (Oxf). 2022;67(5):816-834. doi: 10.1134/S0006350922050141. Epub 2022 Dec 19.
This paper describes the gangliopexy method, a method for creating a new center of local neurohumoral regulation, based on the formation of new connections discovered between the nervous system and the vascular system. The prospects for the development of this method are studied. At the same time, novel concepts about the cycles of nitric oxide and the superoxide anion radical are introduced. A possible role of these cycles is examined in the protection of cells and the body as a whole against oxidative and nitrosative stress, which develops when (in 5-30% of cases) destructive changes in the displaced ganglion lead to vascular complications and an increased risk of mortality. Mechanisms that can protect nerve cells, prevent the development of destructive changes in these cells and reduce the risk of mortality are also investigated.
本文描述了神经节固定术，这是一种基于神经系统与血管系统之间新发现的连接形成来创建局部神经体液调节新中心的方法。研究了该方法的发展前景。同时，引入了关于一氧化氮和超氧阴离子自由基循环的新概念。研究了这些循环在保护细胞和整个身体免受氧化和亚硝化应激方面的可能作用，氧化和亚硝化应激在（5% - 30%的病例中）移位神经节的破坏性变化导致血管并发症和死亡风险增加时会出现。还研究了能够保护神经细胞、防止这些细胞发生破坏性变化并降低死亡风险的机制。
