Chen Chao, Xi Yuewei, Weng Yunxuan
College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, China.
Materials (Basel). 2022 Mar 15;15(6):2164. doi: 10.3390/ma15062164.
Over the last few decades, tissue engineering has become an important technology for repairing and rebuilding damaged tissues and organs. The scaffold plays an important role and has become a hot pot in the field of tissue engineering. It has sufficient mechanical and biochemical properties and simulates the structure and function of natural tissue to promote the growth of cells inward. Therefore, graphene-based nanomaterials (GBNs), such as graphene and graphene oxide (GO), have attracted wide attention in the field of biomedical tissue engineering because of their unique structure, large specific surface area, good photo-thermal effect, pH response and broad-spectrum antibacterial properties. In this review, the structure and properties of typical GBNs are summarized, the progress made in the development of GBNs in soft tissue engineering (including skin, muscle, nerve and blood vessel) are highlighted, the challenges and prospects of the application of GBNs in soft tissue engineering have prospected.
在过去几十年里，组织工程已成为修复和重建受损组织与器官的一项重要技术。支架发挥着重要作用，并且已成为组织工程领域的一个热点。它具有足够的机械和生化特性，能够模拟天然组织的结构和功能，以促进细胞向内生长。因此，基于石墨烯的纳米材料（GBNs），如石墨烯和氧化石墨烯（GO），因其独特的结构、大比表面积、良好的光热效应、pH响应和广谱抗菌性能，在生物医学组织工程领域引起了广泛关注。在这篇综述中，总结了典型GBNs的结构和特性，突出了GBNs在软组织工程（包括皮肤、肌肉、神经和血管）发展方面取得的进展，展望了GBNs在软组织工程应用中的挑战和前景。
