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本文引用的文献

1
Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. I. Characteristics of Mutants and Genetic Mapping of Alleles.酵母氨酸生物合成的第一个基因中的等位基因互补。I. 突变体的特征和等位基因的遗传图谱。
Genetics. 1973 Jun;74(2):287-305. doi: 10.1093/genetics/74.2.287.
2
ALLELIC MAPPING IN YEAST BY X-RAY-INDUCED MITOTIC REVERSION.通过X射线诱导的有丝分裂逆转在酵母中进行等位基因定位
Science. 1964 Feb 7;143(3606):581-3. doi: 10.1126/science.143.3606.581.
3
On the nature of the glutamic dehydrogenase produced by inter-allele complementation at the am locus of Neurospora crassa.关于粗糙脉孢菌am基因座上等位基因间互补产生的谷氨酸脱氢酶的性质
J Gen Microbiol. 1959 Dec;21:600-11. doi: 10.1099/00221287-21-3-600.
4
Informational transfer in meiotic gene conversion.减数分裂基因转换中的信息传递。
Proc Natl Acad Sci U S A. 1969 Jan;62(1):96-103. doi: 10.1073/pnas.62.1.96.
5
Conversion-associated recombination in yeast (hybrids-meiosis-tetrads-marker loci-models).酵母中的转换相关重组（杂种-减数分裂-四分体-标记基因座-模型）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):101-5. doi: 10.1073/pnas.69.1.101.
6
Mitotic chromosome loss in a disomic haploid of Saccharomyces cerevisiae.酿酒酵母二体单倍体中的有丝分裂染色体丢失
Genetics. 1975 Mar;79(3):383-96. doi: 10.1093/genetics/79.3.383.

酵母 his1 基因座处的新型等位基因间互补。

Novel interallelic complementation at the his1 locus of yeast.

作者信息

Lax C, Fogel S

出版信息

Genetics. 1978 Nov;90(3):501-16. doi: 10.1093/genetics/90.3.501.

DOI:10.1093/genetics/90.3.501
PMID:365680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213903/
Abstract

In yeast, 17 histidine-requiring mutants derived from and interallelically complementary to his1-7 were analyzed. The genetic basis of the complementation response was elucidated by mitotic and meiotic gene conversion. Each allele probably carries an unaltered 7-site mutation and a unique second-site alteration. The second-site alterations appear to be clustered within the proximal and distal segments of the his1 structural gene. Models of intraalelic complementation are reviewed in light of the unique complementational response between a single-site mutant and a double mutant including the identical altered base sequence.

摘要

在酵母中，对源自his1-7且与之等位基因互补的17个组氨酸需求型突变体进行了分析。通过有丝分裂和减数分裂基因转换阐明了互补反应的遗传基础。每个等位基因可能携带一个未改变的7位点突变和一个独特的第二位点改变。第二位点改变似乎聚集在his1结构基因的近端和远端区段内。根据单一位点突变体与双突变体（包括相同改变碱基序列）之间独特的互补反应，对基因内互补模型进行了综述。