Cui Hongchang, Guo Chaoqun, Wang Qian, Feng Congrui, Duan Zhi
Qingdao Vland Biotech Group Co., Ltd., Qingdao, China.
Front Med (Lausanne). 2022 Dec 9;9:1064460. doi: 10.3389/fmed.2022.1064460. eCollection 2022.
Acne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was to investigate the efficacy of an anti-acne lotion in alleviating acne.
In our study, an anti-acne lotion containing ferment lysate produced by VHProbi E15 were applied to subjects with mild -to -moderate acne over 4 weeks. The efficacy was evaluated based on instrumental measurements using Visia-CR and CK-MPA system.
The anti-acne lotion exhibited favorable safety, meeting the stringent criteria for the detection of microbes, heavy metals, toxicity, and irritation. After 2 weeks of treatment, a statistically significant improvement in acne lesions was observed compared to baseline ( < 0.01), and this continued to the end of the study. After 4 weeks of treatment, the transepidermal water loss ( < 0.05) and sebum production ( < 0.05) were significantly decreased in subjects compared to baseline. In addition, the pore/area of interest (AOI) and stratum corneum hydration displayed slightly positive changes throughout treatment. Thus, we conclude that applying topical anti-acne lotion may be safe and confer effective benefits in people with mild -to -moderate acne and represents a promising therapeutic option for acne.
痤疮会损害面部美观并成为一种心理负担，尤其是在青春期出现时。在某些情况下，具有抗痤疮功效的护肤化妆品比其他治疗方式（如膳食补充剂）更方便。本研究的目的是调查一种抗痤疮乳液在减轻痤疮方面的功效。
在我们的研究中，一种含有VHProbi E15产生的发酵裂解物的抗痤疮乳液被应用于轻度至中度痤疮患者4周。基于使用Visia-CR和CK-MPA系统的仪器测量来评估疗效。
该抗痤疮乳液表现出良好的安全性，符合微生物、重金属、毒性和刺激性检测的严格标准。治疗2周后，与基线相比，痤疮损伤有统计学意义的改善（<0.01），并且这种改善持续到研究结束。治疗4周后，与基线相比，受试者的经表皮水分流失（<0.05）和皮脂分泌（<0.05）显著降低。此外，在整个治疗过程中，感兴趣的毛孔/区域（AOI）和角质层水合作用显示出轻微的积极变化。因此，我们得出结论，局部应用抗痤疮乳液可能对轻度至中度痤疮患者是安全且有效的，是一种有前景的痤疮治疗选择。
