Tebcherany Houda, Grandhi Anupama, Khocht Ahmed
General Dentistry, Loma Linda University School of Dentistry, Loma Linda, USA.
Oral & Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, USA.
Cureus. 2022 Nov 21;14(11):e31739. doi: 10.7759/cureus.31739. eCollection 2022 Nov.
The human papillomavirus (HPV) is a non-enveloped DNA virus that causes a variety of skin and mucosal lesions. This report reviews a likely HPV-related lesion of oral squamous cell papilloma clinically mimicking oral verrucous leukoplakia. A 71-year-old white male presented with a raised white lesion on the palatal mucosa. It felt hard on palpation and had a sessile fixed base, and a rough verrucous surface. The lesion was fully excised. Histopathology showed short, thin, fingerlike projections lined by stratified squamous epithelium with thin central connective tissue cores. The epithelial superficial layers demonstrated focal koilocytotic changes suggestive of an HPV infection. High-risk HPV-related lesions have the potential to turn malignant. Early diagnosis and management are critical to preventing serious complications.
人乳头瘤病毒（HPV）是一种无包膜的DNA病毒，可引起多种皮肤和黏膜病变。本报告回顾了一例临床上酷似口腔疣状白斑的可能与HPV相关的口腔鳞状细胞乳头状瘤病变。一名71岁的白人男性腭黏膜出现一个隆起的白色病变。触诊时感觉质地硬，有蒂状固定基底，表面粗糙呈疣状。该病变被完整切除。组织病理学显示有短而细的指状突起，由复层鳞状上皮衬里，中央有薄的结缔组织核心。上皮表层显示局灶性空泡细胞改变，提示HPV感染。高危HPV相关病变有恶变的可能。早期诊断和处理对于预防严重并发症至关重要。
