Thompson J N
Department of Surgery, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.
Laryngoscope. 1987 Oct;97(10):1191-202. doi: 10.1288/00005537-198710000-00014.
The unique clinical experience of having to treat simultaneously nine young adults who had ingested the same corrosive substance prompted this investigation in rabbits of the pathophysiology of corrosive esophageal injury and of drugs that might prevent formation of stricture. Treatment of experimental corrosive esophageal injury in these animals consisted of antegrade dilatation and administration of two lathyrogenic drugs, colchicine and penicillamine, in various combinations. This study demonstrated that the rabbit can serve as a suitable animal model for study of corrosive injury of the esophagus, that penicillamine given alone affected wound healing with less severe stricture after such an injury, and that colchicine was associated with delayed wound healing and severe stricture.
必须同时治疗九名摄入了相同腐蚀性物质的年轻成年人，这种独特的临床经历促使人们对家兔腐蚀性食管损伤的病理生理学以及可能预防狭窄形成的药物展开了此项研究。对这些动物的实验性腐蚀性食管损伤的治疗包括顺行扩张以及以各种组合方式给予两种致纤维化药物秋水仙碱和青霉胺。这项研究表明，家兔可作为研究食管腐蚀性损伤的合适动物模型，单独给予青霉胺会影响伤口愈合，且在此类损伤后狭窄程度较轻，而秋水仙碱与伤口愈合延迟和严重狭窄有关。
