Ekingen G, Ozden M, Sözübir S, Maral H, Müezzinoğlu B, Kahraman H, Güvenç B H
Department of Pediatric Surgery, Medical School of Kocaeli University, Kocaeli, Turkey.
Pediatr Surg Int. 2005 Jun;21(6):441-4. doi: 10.1007/s00383-005-1429-2. Epub 2005 Apr 28.
Previous experimental studies have suggested that administration of antithrombotic, antioxidant, and cytoprotective agents have protective effects in caustic injury of the esophagus. Therefore, an experimental study was carried out to investigate the effects of iloprost, a stable analogue of prostacyclin, on the esophagus after caustic burns. Sixty Wistar albino rats were divided into three groups of 20 animals each. In group A, animals were uninjured and untreated. In group B, animals were injured but untreated. In group C, rats were injured and administered intravenous iloprost for 3 days. Caustic esophageal burn was produced by 1 ml of 15% NaOH. Efficacy of the treatment was assessed by measuring the tissue malondialdehyde (MDA), superoxide dismutase, and glutathione levels with biochemical methods on the 3rd postoperative day. Histopathological evaluation was done on the 28th postoperative day. The level of MDA was significantly increased in group B compared with the other groups. In group B, the histopathological damage score was significantly higher than in groups A and C. There was also a significant difference between groups A and C regarding the histopathologic damage. These results indicate that iloprost has a preventive effect in experimental caustic esophageal burn in rats.
先前的实验研究表明，给予抗血栓、抗氧化和细胞保护剂对食管腐蚀性损伤具有保护作用。因此，进行了一项实验研究，以探讨前列环素的稳定类似物伊洛前列素对大鼠食管腐蚀性烧伤后的影响。60只Wistar白化大鼠被分为三组，每组20只。A组动物未受伤且未接受治疗。B组动物受伤但未接受治疗。C组大鼠受伤并静脉注射伊洛前列素3天。用1ml 15%氢氧化钠造成食管腐蚀性烧伤。在术后第3天，通过生化方法测量组织丙二醛（MDA）、超氧化物歧化酶和谷胱甘肽水平来评估治疗效果。在术后第28天进行组织病理学评估。与其他组相比，B组的MDA水平显著升高。在B组中，组织病理学损伤评分显著高于A组和C组。A组和C组在组织病理学损伤方面也存在显著差异。这些结果表明，伊洛前列素对大鼠实验性食管腐蚀性烧伤具有预防作用。
